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anti-TET1 antibody :: Rabbit TET1 Antibody

Scan QR to view Datasheet Catalog #    MBS8502263
Western Blot (WB)
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TET1, Antibody

★Popular Item★
 Also Known As   

TET1 Antibody

 Product Synonym Names    LCX; CXXC6; bA119F7.1; TET1
 Product Gene Name   

anti-TET1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607790
 3D Structure    ModBase 3D Structure for Q8NFU7
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human TET1
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TET1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TET1 antibody

   TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2, 136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1, 200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
 Product Categories/Family for anti-TET1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-TET1 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-TET1 antibody    WB: 1:500-1:2000
IP: 1:20-1:100
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 Western Blot (WB) of anti-TET1 antibody    Western blot analysis of extracts of A431 celllines, using TET1 antibody.
anti-TET1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TET1. It may not necessarily be applicable to this product.
 NCBI GI #    156139122
 NCBI GeneID    80312
 NCBI Accession #    NP_085128.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030625.2 [Other Products]
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 UniProt Primary Accession #    Q8NFU7 [Other Products]
 UniProt Secondary Accession #    Q5VUP7; Q7Z6B6; Q8TCR1; Q9C0I7 [Other Products]
 UniProt Related Accession #    Q8NFU7 [Other Products]
 Molecular Weight    235kDa
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 NCBI Official Full Name    methylcytosine dioxygenase TET1
 NCBI Official Synonym Full Names    tet methylcytosine dioxygenase 1
 NCBI Official Symbol    TET1 [Similar Products]
 NCBI Official Synonym Symbols   
LCX; CXXC6; bA119F7.1
[Similar Products]
 NCBI Protein Information    methylcytosine dioxygenase TET1
 UniProt Protein Name    Methylcytosine dioxygenase TET1
 UniProt Synonym Protein Names   
CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein
 Protein Family    Methylcytosine dioxygenase
 UniProt Gene Name    TET1 [Similar Products]
 UniProt Synonym Gene Names    CXXC6; KIAA1676; LCX [Similar Products]
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 NCBI Summary for TET1    DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
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 UniProt Comments for TET1    Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
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 Research Articles on TET1    1. Although DNA methylation (5mC) and hydroxymethylation (5hmC) are highly dynamic during early embryonic development, less is known about their roles at later stages of differentiation. 5hmC marks HNF4A promoter 1 previous to terminal hepatocyte differentiation. TET1-dependent 5hmC is required to activate promoter 1-driven HNF4A expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TET1 antibodyPathways associated with anti-TET1 antibody
 Reference Product  PubMed Publications
 DNMT3A antibody  >15 publications with TET1 and DNMT3A
 DNMT3B antibody  >15 publications with TET1 and DNMT3B
 NANOG antibody  >10 publications with TET1 and NANOG
 SIN3A antibody  >4 publications with TET1 and SIN3A
 MBD3 antibody  >1 publications with TET1 and MBD3
 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram
Diseases associated with anti-TET1 antibodyOrgans/Tissues associated with anti-TET1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >19 publications with TET1 and Nervous System Diseases
 Brain Diseases Antibodies  >13 publications with TET1 and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with TET1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with TET1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >3 publications with TET1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with TET1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with TET1 and Inflammation
 Liver Neoplasms Antibodies  >2 publications with TET1 and Liver Neoplasms
 Hypertension Antibodies  >2 publications with TET1 and Hypertension
 Muscular Diseases Antibodies  >2 publications with TET1 and Muscular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with TET1 and Brain
 Embryonic Tissue Antibodies  >14 publications with TET1 and Embryonic Tissue
 Bone Antibodies  >5 publications with TET1 and Bone
 Lung Antibodies  >5 publications with TET1 and Lung
 Testis Antibodies  >4 publications with TET1 and Testis
 Prostate Antibodies  >4 publications with TET1 and Prostate
 Thymus Antibodies  >3 publications with TET1 and Thymus
 Eye Antibodies  >3 publications with TET1 and Eye
 Lymph Node Antibodies  >3 publications with TET1 and Lymph Node
 Heart Antibodies  >3 publications with TET1 and Heart
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