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anti-TFEB antibody :: anti-Human, Mouse TFEB Antibody

Scan QR to view Datasheet Catalog #    MBS8512514
Western Blot (WB)
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFEB, Antibody

★Popular Item★
 Also Known As   

TFEB Antibody

 Product Synonym Names    ALPHATFEB; BHLHE35; Class E basic helix-loop-helix protein 35; T-cell transcription factor EB; TCFEB; TFEB; Transcription factor EB
 Product Gene Name   

anti-TFEB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M33782 mRNA
 3D Structure    ModBase 3D Structure for P19484
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 Species Reactivity    Human, Mouse
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 Specificity    TFEB Antibody detects endogenous levels of total TFEB
 Purity/Purification    Immunogen Affinity Purified
 Form/Format    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    A synthesized peptide derived from human TFEB
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TFEB antibody

   TFEB Probable transcription factor binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
 Applications Tested/Suitable for anti-TFEB antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TFEB antibody    WB: 1: 500-1: 2000
IHC: 1: 50-1: 200
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 Western Blot (WB) of anti-TFEB antibody    Western blot analysis of TFEB expression in Mouse lungtissue lysates, The lane on the left is treated with the antigen-specific peptide.
anti-TFEB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
 NCBI GI #    429836865
 NCBI GeneID    7942
 NCBI Accession #    NP_001161299.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001167827.2 [Other Products]
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 UniProt Primary Accession #    P19484 [Other Products]
 UniProt Secondary Accession #    Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8 [Other Products]
 UniProt Related Accession #    P19484 [Other Products]
 Molecular Weight    52kDa [Similar Products]
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 NCBI Official Full Name    transcription factor EB isoform 2
 NCBI Official Synonym Full Names    transcription factor EB
 NCBI Official Symbol    TFEB [Similar Products]
 NCBI Official Synonym Symbols   
TCFEB; BHLHE35; ALPHATFEB
[Similar Products]
 NCBI Protein Information    transcription factor EB
 UniProt Protein Name    Transcription factor EB
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 35; bHLHe35
 Protein Family    Transcription factor
 UniProt Gene Name    TFEB [Similar Products]
 UniProt Synonym Gene Names    BHLHE35; bHLHe35 [Similar Products]
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 UniProt Comments for TFEB    TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: transcription factor activity

Biological Process: embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on TFEB    1. Neuronal C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFEB antibodyDiseases associated with anti-TFEB antibody
 Reference Product  PubMed Publications
 TFE3 antibody  >52 publications with TFEB and TFE3
 MITF antibody  >37 publications with TFEB and MITF
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >41 publications with TFEB and Neoplasms
 Death Antibodies  >13 publications with TFEB and Death
 Nervous System Diseases Antibodies  >8 publications with TFEB and Nervous System Diseases
 Heart Diseases Antibodies  >6 publications with TFEB and Heart Diseases
 Congenital Abnormalities Antibodies  >4 publications with TFEB and Congenital Abnormalities
 Drug Toxicity Antibodies  >4 publications with TFEB and Drug Toxicity
 Immune System Diseases Antibodies  >3 publications with TFEB and Immune System Diseases
 Movement Disorders Antibodies  >2 publications with TFEB and Movement Disorders
 Cell Transformation, Neoplastic Antibodies  >2 publications with TFEB and Cell Transformation, Neoplastic
 Multiple Myeloma Antibodies  >2 publications with TFEB and Multiple Myeloma
Organs/Tissues associated with anti-TFEB antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >37 publications with TFEB and Kidney
 Blood Antibodies  >13 publications with TFEB and Blood
 Muscle Antibodies  >10 publications with TFEB and Muscle
 Placenta Antibodies  >6 publications with TFEB and Placenta
 Bone Antibodies  >6 publications with TFEB and Bone
 Eye Antibodies  >4 publications with TFEB and Eye
 Skin Antibodies  >3 publications with TFEB and Skin
 Lung Antibodies  >3 publications with TFEB and Lung
 Lymph Antibodies  >3 publications with TFEB and Lymph
 Lymph Node Antibodies  >3 publications with TFEB and Lymph Node
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