Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TFII-I  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • HIPK4 Antibody
 • GAB2 (Phospho-Ser159) Antibody
 • CA5B Antibody
 • Fibroblast Growth Factor 23 (FGF-23) ELISA Kit
 • Insulin Receptor Substrate 2 (IRS-2) ELISA Kit
 • C-Myc Oncogene Product ELISA Kit
 • Helicobacter Pylori Caga (HP-CAGA) ELISA Kit
 • Integrin beta4 (ITGbeta4) ELISA Kit
 • Adenosine Monophosphate Activated Protein (AMPK) ELISA Kit
 • Complement Factor B (CFB) ELISA Kit
 • Transferrin Receptor (TFR) ELISA Kit
 • Cathepsin C (CTSC) ELISA Kit
 • Fibroblast Surface Protein (FSP) ELISA Kit
 • Melatonin (MLT) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TFII-I antibody :: Rabbit TFII-I (Phospho-Tyr248) Antibody

Scan QR to view Datasheet Catalog #    MBS001051 anti-TFII-I antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFII-I (Phospho-Tyr248), Antibody

 Also Known As   

Rabbit TFII-I (Phospho-Tyr248) Antibody

 Product Gene Name   

anti-TFII-I antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 7; NC_000007.13 (74072030..74175022). Location: 7q11.23
 OMIM    601679
 3D Structure    ModBase 3D Structure for P78347
Section Bar
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-TFII-I antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-TFII-I antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TFII-I. It may not necessarily be applicable to this product.
 NCBI GI #    254692934
 NCBI GeneID    2969
 NCBI Accession #    NP_001157108.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163636.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P78347 [Other Products]
 UniProt Secondary Accession #    O14743; O15359; O43546; O43588; O43589; Q75M85; Q75M86; Q75M87; Q75M88; Q9BSZ4 [Other Products]
 UniProt Related Accession #    P78347 [Other Products]
 Molecular Weight    112,416 Da
Table BarTOPTable Bar
 NCBI Official Full Name    general transcription factor II-I isoform 5
 NCBI Official Synonym Full Names    general transcription factor IIi
 NCBI Official Symbol    GTF2I [Similar Products]
 NCBI Official Synonym Symbols   
WBS; DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; GTFII-I
[Similar Products]
 NCBI Protein Information    general transcription factor II-I; BTK-associated protein 135; BTK-associated protein, 135kD; SRF-Phox1-interacting protein; Williams-Beuren syndrome chromosome region 6; Bruton tyrosine kinase-associated protein 135; williams-Beuren syndrome chromosomal region 6 protein
 UniProt Protein Name    General transcription factor II-I
 UniProt Synonym Protein Names   
Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region 6 protein
 UniProt Gene Name    GTF2I [Similar Products]
 UniProt Synonym Gene Names    BAP135; WBSCR6; GTFII-I; TFII-I; BAP-135; BTK-associated protein 135; SPIN [Similar Products]
 UniProt Entry Name    GTF2I_HUMAN
Section Bar
 NCBI Summary for TFII-I    This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21. [provided by RefSeq, Jul 2009]
Section Bar
 UniProt Comments for TFII-I    GTF2I: a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: nucleoplasm; cell projection; membrane; cell soma; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; mitogen-activated protein kinase binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of angiogenesis; regulation of transcription, DNA-dependent; transition between slow and fast fiber; reduction of cytosolic calcium ion concentration; signal transduction

Disease: Williams-beuren Syndrome
Table BarTOPTable Bar
 Research Articles on TFII-I    1. Our findings suggest the GTF2i gene is important in the etiology of autism in individuals with this duplication and in non-duplication cases with severe social interaction problems and repetitive behaviors.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TFII-I antibodyPathways associated with anti-TFII-I antibody
 Reference Product  PubMed Publications
 SRC antibody  >7 publications with TFII-I and SRC
 USF1 antibody  >6 publications with TFII-I and USF1
 BTK antibody  >5 publications with TFII-I and BTK
 SMAD2 antibody  >2 publications with TFII-I and SMAD2
 HDAC3 antibody  >2 publications with TFII-I and HDAC3
 YY1 antibody  >1 publications with TFII-I and YY1
 STAT3 antibody  >1 publications with TFII-I and STAT3
 JAK2 antibody  >1 publications with TFII-I and JAK2
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-TFII-I antibodyOrgans/Tissues associated with anti-TFII-I antibody
 Disease Name  Pubmed Publications
 Williams Syndrome Antibodies  >49 publications with TFII-I and Williams Syndrome
 Neoplasms Antibodies  >6 publications with TFII-I and Neoplasms
 Carcinoma Antibodies  >3 publications with TFII-I and Carcinoma
 Prostatic Diseases Antibodies  >2 publications with TFII-I and Prostatic Diseases
 Child Development Disorders, Pervasive Antibodies  >2 publications with TFII-I and Child Development Disorders, Pervasive
 Weight Loss Antibodies  >1 publications with TFII-I and Weight Loss
 Inflammation Antibodies  >1 publications with TFII-I and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with TFII-I and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with TFII-I and Liver Neoplasms
 Hyperplasia Antibodies  >1 publications with TFII-I and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >24 publications with TFII-I and Muscle
 Brain Antibodies  >24 publications with TFII-I and Brain
 Blood Antibodies  >15 publications with TFII-I and Blood
 Nerve Antibodies  >7 publications with TFII-I and Nerve
 Vascular Antibodies  >6 publications with TFII-I and Vascular
 Embryonic Tissue Antibodies  >5 publications with TFII-I and Embryonic Tissue
 Heart Antibodies  >5 publications with TFII-I and Heart
 Connective Tissue Antibodies  >5 publications with TFII-I and Connective Tissue
 Bone Antibodies  >3 publications with TFII-I and Bone
 Eye Antibodies  >2 publications with TFII-I and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions