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anti-TGFBR1 antibody :: Rabbit anti-Human, Mouse TGF beta Receptor I Antibody

Scan QR to view Datasheet Catalog #    MBS852142
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta Receptor I (TGFBR1), Antibody

 Also Known As   

TGF beta Receptor I (Ab-165) Antibody

 Product Synonym Names    TGF b Receptor I (Ab-165) Antibody; ADRB2; ALK-5; Activin receptor-like kinase 5; EC 2.7.11.30; ESK2; SKR4; TGF-beta receptor type I precursor; TGF-beta type I receptor; TGF-betaR1; TGFR-1; TGFR1; kinase TGF-beta-R1; receptor R4
 Product Gene Name   

anti-TGFBR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609192
 3D Structure    ModBase 3D Structure for P36897
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    TGF beta Receptor I (Ab-165) antibody detects endogenous levels of total TGF beta Receptor I protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human TGF beta Receptor I around the phosphorylation site ofserine 165 (D-P-SP-L-D).
 Pathway    Receptors
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-TGFBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TGFBR1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-TGFBR1 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-TGFBR1 antibody    WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:10000
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 Testing Data of anti-TGFBR1 antibody    anti-TGFBR1 antibody Testing Data image
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 Testing Data #2 of anti-TGFBR1 antibody    Peptide - +
Western blot analysis of extracts from COLO cells and HepG2 cells, using TGF beta Receptor I (Ab-165) antibody.
Immunofluorescence analysis of HeLa cells, using TGF beta Receptor I (Ab-165) antibody.
anti-TGFBR1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for TGFBR1. It may not necessarily be applicable to this product.
 NCBI GI #    195963412
 NCBI GeneID    7046
 NCBI Accession #    NP_001124388.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130916.1 [Other Products]
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 UniProt Primary Accession #    P36897 [Other Products]
 UniProt Secondary Accession #    Q6IR47; Q706C0; Q706C1 [Other Products]
 UniProt Related Accession #    P36897 [Other Products]
 Molecular Weight    47,690 Da [Similar Products]
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 NCBI Official Full Name    TGF-beta receptor type-1 isoform 2
 NCBI Official Synonym Full Names    transforming growth factor, beta receptor 1
 NCBI Official Symbol    TGFBR1 [Similar Products]
 NCBI Official Synonym Symbols   
AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4
[Similar Products]
 NCBI Protein Information    TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
 UniProt Protein Name    TGF-beta receptor type-1
 UniProt Synonym Protein Names   
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
 Protein Family    TGF-beta receptor
 UniProt Gene Name    TGFBR1 [Similar Products]
 UniProt Synonym Gene Names    ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I [Similar Products]
 UniProt Entry Name    TGFR1_HUMAN
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 NCBI Summary for TGFBR1    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for TGFBR1    TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: Kinase, protein; EC 2.7.11.30; Protein kinase, TKL; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; receptor complex; endosome

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; metal ion binding; receptor signaling protein activity; punt binding; SMAD binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; activin receptor signaling pathway; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; cell cycle arrest; kidney development; neuron fate commitment; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; regulation of protein ubiquitination; apoptosis; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
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Product References and Citations for anti-TGFBR1 antibody

   Franzen P., Cell 75:681-692(1993).
Vellucci V.F., Genomics 46:278-283(1997).
Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on TGFBR1    1. data demonstrate that miR-142-3p influences the proliferation of non-small cell lung cancer cells through repression of TGFbetaR1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFBR1 antibodyPathways associated with anti-TGFBR1 antibody
 Reference Product  PubMed Publications
 TGFBR2 antibody  >125 publications with TGFBR1 and TGFBR2
 TGFB1 antibody  >61 publications with TGFBR1 and TGFB1
 SMAD2 antibody  >29 publications with TGFBR1 and SMAD2
 SMAD7 antibody  >15 publications with TGFBR1 and SMAD7
 SMAD4 antibody  >14 publications with TGFBR1 and SMAD4
 TGFB3 antibody  >9 publications with TGFBR1 and TGFB3
 SMURF2 antibody  >1 publications with TGFBR1 and SMURF2
 UBC antibody  >1 publications with TGFBR1 and UBC
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TGFBR1 antibodyOrgans/Tissues associated with anti-TGFBR1 antibody
 Disease Name  Pubmed Publications
 Loeys-Dietz Syndrome Antibodies  >63 publications with TGFBR1 and Loeys-Dietz Syndrome
 Heart Diseases Antibodies  >48 publications with TGFBR1 and Heart Diseases
 Aneurysm, Dissecting Antibodies  >35 publications with TGFBR1 and Aneurysm, Dissecting
 Colorectal Neoplasms Antibodies  >31 publications with TGFBR1 and Colorectal Neoplasms
 Inflammation Antibodies  >12 publications with TGFBR1 and Inflammation
 Lung Diseases Antibodies  >10 publications with TGFBR1 and Lung Diseases
 Fibrosis Antibodies  >10 publications with TGFBR1 and Fibrosis
 Neoplasms, Experimental Antibodies  >9 publications with TGFBR1 and Neoplasms, Experimental
 Pain Antibodies  >7 publications with TGFBR1 and Pain
 Lung Neoplasms Antibodies  >6 publications with TGFBR1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >52 publications with TGFBR1 and Vascular
 Connective Tissue Antibodies  >38 publications with TGFBR1 and Connective Tissue
 Blood Antibodies  >37 publications with TGFBR1 and Blood
 Muscle Antibodies  >30 publications with TGFBR1 and Muscle
 Heart Antibodies  >26 publications with TGFBR1 and Heart
 Lung Antibodies  >26 publications with TGFBR1 and Lung
 Bone Antibodies  >23 publications with TGFBR1 and Bone
 Skin Antibodies  >15 publications with TGFBR1 and Skin
 Embryonic Tissue Antibodies  >13 publications with TGFBR1 and Embryonic Tissue
 Kidney Antibodies  >13 publications with TGFBR1 and Kidney
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