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anti-TGFR-1 antibody :: anti-Human, Mouse TGF beta Receptor I Antibody

Scan QR to view Datasheet Catalog #    MBS852142
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta Receptor I (TGFR-1), Antibody

 Also Known As   

TGF beta Receptor I (Ab-165) Antibody

 Product Synonym Names    ADRB2; ALK-5; Activin receptor-like kinase 5; EC 2.7.11.30; ESK2; SKR4; TGF-beta receptor type I precursor; TGF-beta type I receptor; TGF-betaR1; TGFR1; kinase TGF-beta-R1; receptor R4
 Product Gene Name   

anti-TGFR-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    132800
 3D Structure    ModBase 3D Structure for P36897
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 Species Reactivity    Human, Mouse
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 Specificity    TGF beta Receptor I (Ab-165) antibody detects endogenous levels of total TGF beta Receptor I protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human TGF beta Receptor I around the phosphorylation site ofserine 165 (D-P-SP-L-D).
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-TGFR-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TGFR-1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-TGFR-1 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-TGFR-1 antibody    WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000
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 Testing Data of anti-TGFR-1 antibody    anti-TGFR-1 antibody Testing Data image
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 Western Blot (WB) of anti-TGFR-1 antibody    Peptide-+ Western blot analysis of extracts from COLO cells and HepG2 cells, using TGF beta Receptor I (Ab-165) antibody. Immunofluorescence analysis of HeLa cells, using TGF beta Receptor I (Ab-165) antibody.
anti-TGFR-1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TGFR-1. It may not necessarily be applicable to this product.
 NCBI GI #    195963412
 NCBI GeneID    7046
 NCBI Accession #    NP_001124388.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130916.2 [Other Products]
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 UniProt Primary Accession #    P36897 [Other Products]
 UniProt Secondary Accession #    Q6IR47; Q706C0; Q706C1 [Other Products]
 UniProt Related Accession #    P36897 [Other Products]
 Molecular Weight    47,690 Da
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 NCBI Official Full Name    TGF-beta receptor type-1 isoform 2
 NCBI Official Synonym Full Names    transforming growth factor beta receptor 1
 NCBI Official Symbol    TGFBR1 [Similar Products]
 NCBI Official Synonym Symbols   
AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; TBRI; ALK-5; LDS1A; LDS2A; TBR-i; TGFR-1; ACVRLK4; tbetaR-I
[Similar Products]
 NCBI Protein Information    TGF-beta receptor type-1
 UniProt Protein Name    TGF-beta receptor type-1
 UniProt Synonym Protein Names   
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
 UniProt Gene Name    TGFBR1 [Similar Products]
 UniProt Synonym Gene Names    ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I [Similar Products]
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 NCBI Summary for TGFR-1    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for TGFR-1    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
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Product References and Citations for anti-TGFR-1 antibody

   Franzen P., Cell 75:681-692(1993). Vellucci V.F., Genomics 46:278-283(1997). Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on TGFR-1    1. DZNep induced miR-202-5p to target both TGFbeta receptors, TGFBR1 and TGFBR2...transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFR-1 antibodyPathways associated with anti-TGFR-1 antibody
 Reference Product  PubMed Publications
 TGFBR2 antibody  >106 publications with TGFR-1 and TGFBR2
 TGFB1 antibody  >47 publications with TGFR-1 and TGFB1
 SMAD2 antibody  >22 publications with TGFR-1 and SMAD2
 SMAD3 antibody  >19 publications with TGFR-1 and SMAD3
 SMAD7 antibody  >14 publications with TGFR-1 and SMAD7
 SMAD4 antibody  >12 publications with TGFR-1 and SMAD4
 TGFB2 antibody  >9 publications with TGFR-1 and TGFB2
 TGFB3 antibody  >7 publications with TGFR-1 and TGFB3
 ACVRL1 antibody  >5 publications with TGFR-1 and ACVRL1
 ACVR1 antibody  >4 publications with TGFR-1 and ACVR1
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TGFR-1 antibodyOrgans/Tissues associated with anti-TGFR-1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >82 publications with TGFR-1 and Neoplasms
 Loeys-Dietz Syndrome Antibodies  >47 publications with TGFR-1 and Loeys-Dietz Syndrome
 LOEYS-DIETZ SYNDROME, TYPE 1A Antibodies  >44 publications with TGFR-1 and LOEYS-DIETZ SYNDROME, TYPE 1A
 Heart Diseases Antibodies  >40 publications with TGFR-1 and Heart Diseases
 Colorectal Neoplasms Antibodies  >30 publications with TGFR-1 and Colorectal Neoplasms
 Aneurysm, Dissecting Antibodies  >23 publications with TGFR-1 and Aneurysm, Dissecting
 Inflammation Antibodies  >9 publications with TGFR-1 and Inflammation
 Disease Models, Animal Antibodies  >9 publications with TGFR-1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >7 publications with TGFR-1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >6 publications with TGFR-1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >38 publications with TGFR-1 and Vascular
 Connective Tissue Antibodies  >29 publications with TGFR-1 and Connective Tissue
 Blood Antibodies  >26 publications with TGFR-1 and Blood
 Muscle Antibodies  >20 publications with TGFR-1 and Muscle
 Bone Antibodies  >20 publications with TGFR-1 and Bone
 Heart Antibodies  >15 publications with TGFR-1 and Heart
 Lung Antibodies  >14 publications with TGFR-1 and Lung
 Embryonic Tissue Antibodies  >11 publications with TGFR-1 and Embryonic Tissue
 Skin Antibodies  >11 publications with TGFR-1 and Skin
 Kidney Antibodies  >11 publications with TGFR-1 and Kidney
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