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anti-TGFBR2 antibody :: Rabbit anti-Human, mouse TGF beta Receptor II (Ab-250) Antibody

Scan QR to view Datasheet Catalog #    MBS004195 anti-TGFBR2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta Receptor II (Ab-250) (TGFBR2), Antibody

 Also Known As   

Rabbit TGF beta Receptor II (Ab-250) Antibody

 Product Synonym Names    TGF b Receptor II (Ab-250)
 Product Gene Name   

anti-TGFBR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (30647994..30735634). Location: 3p22
 OMIM    133239
 3D Structure    ModBase 3D Structure for P37173
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-TGFBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TGFBR2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TGFBR2. It may not necessarily be applicable to this product.
 NCBI GI #    67782326
 NCBI GeneID    7048
 NCBI Accession #    NP_001020018.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024847.2 [Other Products]
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 UniProt Primary Accession #    P37173 [Other Products]
 UniProt Secondary Accession #    Q15580; Q6DKT6; Q99474; B4DTV5 [Other Products]
 UniProt Related Accession #    P37173 [Other Products]
 Molecular Weight    64,568 Da [Similar Products]
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 NCBI Official Full Name    TGF-beta receptor type-2 isoform A
 NCBI Official Synonym Full Names    transforming growth factor, beta receptor II (70/80kDa)
 NCBI Official Symbol    TGFBR2 [Similar Products]
 NCBI Official Synonym Symbols   
AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
[Similar Products]
 NCBI Protein Information    TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC
 UniProt Protein Name    TGF-beta receptor type-2
 UniProt Synonym Protein Names   
TGF-beta type II receptor; Transforming growth factor-beta receptor type II
 Protein Family    TGF-beta receptor
 UniProt Gene Name    TGFBR2 [Similar Products]
 UniProt Synonym Gene Names    TGFR-2; TGF-beta receptor type II; TbetaR-II [Similar Products]
 UniProt Entry Name    TGFR2_HUMAN
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 NCBI Summary for TGFBR2    This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGFBR2    TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.

Protein type: Oncoprotein; Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to membrane; plasma membrane; caveola; cytosol; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: lens development in camera-type eye; wound healing; apoptosis; positive regulation of smooth muscle cell proliferation; heart development; gastrulation; myeloid dendritic cell differentiation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; response to nutrient; positive regulation of T cell tolerance induction; aging; response to drug; blood vessel development; receptor-mediated endocytosis; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; embryonic hemopoiesis; in utero embryonic development; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; positive regulation of angiogenesis; peptidyl-serine phosphorylation; gut development; response to mechanical stimulus; regulation of gene expression; response to estrogen stimulus; positive regulation of B cell tolerance induction; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation

Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Loeys-dietz Syndrome 2; Esophageal Cancer
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 Research Articles on TGFBR2    1. Data indicate that abrogation of TGFbeta signaling through introduction of a dominant negative TGFbeta receptor II (TGFbetaRII) in non-metastatic FETalpha colon cancer cells permits metastasis to distal organs, but does not reduce invasive behavior.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFBR2 antibodyPathways associated with anti-TGFBR2 antibody
 Reference Product  PubMed Publications
 TGFBR1 antibody  >106 publications with TGFBR2 and TGFBR1
 TGFB1 antibody  >53 publications with TGFBR2 and TGFB1
 SMAD4 antibody  >24 publications with TGFBR2 and SMAD4
 SMAD3 antibody  >23 publications with TGFBR2 and SMAD3
 TGFB2 antibody  >17 publications with TGFBR2 and TGFB2
 CTNNB1 antibody  >12 publications with TGFBR2 and CTNNB1
 TGFBR3 antibody  >10 publications with TGFBR2 and TGFBR3
 SMAD7 antibody  >10 publications with TGFBR2 and SMAD7
 ACVRL1 antibody  >7 publications with TGFBR2 and ACVRL1
 TGFB3 antibody  >7 publications with TGFBR2 and TGFB3
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TGFBR2 antibodyOrgans/Tissues associated with anti-TGFBR2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >132 publications with TGFBR2 and Neoplasms
 Marfan Syndrome Antibodies  >72 publications with TGFBR2 and Marfan Syndrome
 Aortic Aneurysm Antibodies  >67 publications with TGFBR2 and Aortic Aneurysm
 Loeys-Dietz Syndrome Antibodies  >58 publications with TGFBR2 and Loeys-Dietz Syndrome
 Bone Diseases Antibodies  >56 publications with TGFBR2 and Bone Diseases
 Carcinoma Antibodies  >56 publications with TGFBR2 and Carcinoma
 Microsatellite Instability Antibodies  >41 publications with TGFBR2 and Microsatellite Instability
 Craniofacial Abnormalities Antibodies  >40 publications with TGFBR2 and Craniofacial Abnormalities
 Aortic Aneurysm, Thoracic Antibodies  >38 publications with TGFBR2 and Aortic Aneurysm, Thoracic
 Aneurysm, Dissecting Antibodies  >34 publications with TGFBR2 and Aneurysm, Dissecting
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >68 publications with TGFBR2 and Vascular
 Connective Tissue Antibodies  >46 publications with TGFBR2 and Connective Tissue
 Bone Antibodies  >44 publications with TGFBR2 and Bone
 Blood Antibodies  >44 publications with TGFBR2 and Blood
 Muscle Antibodies  >38 publications with TGFBR2 and Muscle
 Embryonic Tissue Antibodies  >32 publications with TGFBR2 and Embryonic Tissue
 Heart Antibodies  >27 publications with TGFBR2 and Heart
 Mouth Antibodies  >16 publications with TGFBR2 and Mouth
 Liver Antibodies  >16 publications with TGFBR2 and Liver
 Lung Antibodies  >16 publications with TGFBR2 and Lung
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