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anti-TGF beta1 antibody :: Mouse anti-Human TGF beta1 Antibody

Scan QR to view Datasheet Catalog #    MBS850583
Testing Data
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGF beta1, Antibody

 Also Known As   

TGF beta1 Antibody

 Product Synonym Names    CED; DPD1; TGFB; TGFbeta; TGFB1
 Product Gene Name   

anti-TGF beta1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131300
 3D Structure    ModBase 3D Structure for P01137
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 Isotype    IgG1
 Clone Number    4F9C10; 1B11B7
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of TGF beta1 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-TGF beta1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGF beta1 antibody

   TGF beta(transforming growth factor beta), with 390-amino acid protein (about 43 kDa), is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. In mammals, three isoforms of TGFbeta, that is, beta1, beta2, and beta3, are known. TGF beta is one of numerous inhibitory factors produced by cancer cells that regulate antitumor immunity. TGF beta1 takes part in the local response in the course of primary lung cancer and TGFbeta1 is thought to be implicated in breast cancer progression.TGFbeta1 also plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage.
 Product Categories/Family for anti-TGF beta1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-TGF beta1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-TGF beta1 antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Testing Data of anti-TGF beta1 antibody    Figure 1. Western blot analysis using TGF beta1 mouse mAb against truncated TGF beta1 recombinant protein.
anti-TGF beta1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TGF beta1. It may not necessarily be applicable to this product.
 NCBI GI #    63025222
 NCBI GeneID    7040
 NCBI Accession #    NP_000651.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000660.6 [Other Products]
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 UniProt Primary Accession #    P01137 [Other Products]
 UniProt Secondary Accession #    Q9UCG4; A8K792 [Other Products]
 UniProt Related Accession #    P01137 [Other Products]
 Molecular Weight    44,341 Da
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 NCBI Official Full Name    transforming growth factor beta-1 preproprotein
 NCBI Official Synonym Full Names    transforming growth factor beta 1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Official Synonym Symbols   
CED; LAP; DPD1; TGFB; TGFbeta
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1
 UniProt Protein Name    Transforming growth factor beta-1
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGFB; TGF-beta-1; LAP [Similar Products]
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 NCBI Summary for TGF beta1    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
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 UniProt Comments for TGF beta1    Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).
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 Research Articles on TGF beta1    1. BMP/TGF-beta signaling pathway regulates X-inactive specific transcript (XIST), and whose down-regulation reactivated the methyl CpG binding protein 2 (MeCP2) reporter on the inactive X chromosome (Xi).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGF beta1 antibodyPathways associated with anti-TGF beta1 antibody
 Reference Product  PubMed Publications
 TGFB2 antibody  >983 publications with TGF beta1 and TGFB2
 CTGF antibody  >559 publications with TGF beta1 and CTGF
 ENG antibody  >282 publications with TGF beta1 and ENG
 BMP2 antibody  >205 publications with TGF beta1 and BMP2
 THBS1 antibody  >144 publications with TGF beta1 and THBS1
 MMP2 antibody  >107 publications with TGF beta1 and MMP2
 TGFBR3 antibody  >86 publications with TGF beta1 and TGFBR3
 DCN antibody  >80 publications with TGF beta1 and DCN
 SPARC antibody  >60 publications with TGF beta1 and SPARC
 TGFBR2 antibody  >53 publications with TGF beta1 and TGFBR2
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-TGF beta1 antibodyOrgans/Tissues associated with anti-TGF beta1 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >4145 publications with TGF beta1 and Fibrosis
 Lung Diseases Antibodies  >1277 publications with TGF beta1 and Lung Diseases
 Liver Cirrhosis Antibodies  >723 publications with TGF beta1 and Liver Cirrhosis
 Hypertension Antibodies  >626 publications with TGF beta1 and Hypertension
 Pulmonary Fibrosis Antibodies  >623 publications with TGF beta1 and Pulmonary Fibrosis
 Proteinuria Antibodies  >460 publications with TGF beta1 and Proteinuria
 Diabetic Nephropathies Antibodies  >406 publications with TGF beta1 and Diabetic Nephropathies
 Hypersensitivity Antibodies  >390 publications with TGF beta1 and Hypersensitivity
 Asthma Antibodies  >354 publications with TGF beta1 and Asthma
 Diabetes Mellitus, Experimental Antibodies  >321 publications with TGF beta1 and Diabetes Mellitus, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4785 publications with TGF beta1 and Blood
 Muscle Antibodies  >2835 publications with TGF beta1 and Muscle
 Kidney Antibodies  >2462 publications with TGF beta1 and Kidney
 Bone Antibodies  >2130 publications with TGF beta1 and Bone
 Lung Antibodies  >1764 publications with TGF beta1 and Lung
 Liver Antibodies  >1721 publications with TGF beta1 and Liver
 Connective Tissue Antibodies  >1545 publications with TGF beta1 and Connective Tissue
 Skin Antibodies  >1075 publications with TGF beta1 and Skin
 Heart Antibodies  >1068 publications with TGF beta1 and Heart
 Bone Marrow Antibodies  >709 publications with TGF beta1 and Bone Marrow
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