NP_001265611.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,715 Da
NCBI Official Full Name
homeobox protein TGIF1 isoform e
NCBI Official Synonym Full Names
TGFB induced factor homeobox 1
NCBI Official Synonym Symbols
NCBI Protein Information
homeobox protein TGIF1
UniProt Protein Name
Homeobox protein TGIF1
UniProt Synonym Protein Names
5'-TG-3'-interacting factor 1
UniProt Synonym Gene Names
NCBI Summary for TGIF1
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
UniProt Comments for TGIF1
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Research Articles on TGIF1
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Products associated with anti-TGIF1 antibody
Pathways associated with anti-TGIF1 antibody
Diseases associated with anti-TGIF1 antibody
Organs/Tissues associated with anti-TGIF1 antibody
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