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anti-TLR4 antibody :: Rabbit TLR4 Antibody

Scan QR to view Datasheet Catalog #    MBS8508421
Western Blot
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR4, Antibody

★Popular Item★
 Also Known As   

TLR4 antibody

 Product Synonym Names    TLR4;TLR-4
 Product Gene Name   

anti-TLR4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene+phenotype 611488
 3D Structure    ModBase 3D Structure for O00206
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 Host    Rabbit
 Species Reactivity    Human,Mouse,Rat
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 Specificity    TLR4 antibody detects endogenous levels of total TLR4
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 C.Stable for 12 months from date of receipt
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 Immunogen    A synthesized peptide derived from human TLR4
 Swiss-Prot No.    O00206
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 Preparation and Storage    Storage/Stability: Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-TLR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TLR4 antibody

   Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti fungal response, while the related 18 wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria.
 Applications Tested/Suitable for anti-TLR4 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TLR4 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot of anti-TLR4 antibody    Western blot analysis of TLR4 expression in Hela whole cell lysate. The alne on the left is treated with the antigen-specific peptide.
anti-TLR4 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for TLR4. It may not necessarily be applicable to this product.
 NCBI GI #    20140413
 NCBI GeneID    7099
 NCBI Accession #    O00206.2 [Other Products]
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 UniProt Primary Accession #    O00206 [Other Products]
 UniProt Secondary Accession #    Q5VZI8; Q5VZI9; Q9UK78; Q9UM57; A8K1Y8; A9XLP9; A9XLQ0; A9XLQ1; B4E194; D1CS52; D1CS53 [Other Products]
 UniProt Related Accession #    O00206 [Other Products]
 Molecular Weight    100kDa
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 NCBI Official Full Name    Toll-like receptor 4
 NCBI Official Synonym Full Names    toll-like receptor 4
 NCBI Official Symbol    TLR4 [Similar Products]
 NCBI Official Synonym Symbols   
TOLL; CD284; TLR-4; ARMD10
[Similar Products]
 NCBI Protein Information    toll-like receptor 4; hToll; homolog of Drosophila toll
 UniProt Protein Name    Toll-like receptor 4
 UniProt Synonym Protein Names   
hToll; CD_antigen: CD284
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR4 [Similar Products]
 UniProt Entry Name    TLR4_HUMAN
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 NCBI Summary for TLR4    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for TLR4    TLR4: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3. Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic reticulum. Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. Belongs to the Toll-like receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9q33.1

Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; endosome membrane; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; activation of MAPK activity; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of B cell proliferation; positive regulation of interferon-beta production; negative regulation of interleukin-6 production; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; T-helper 1 type immune response; production of nitric oxide during acute inflammatory response; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; negative regulation of interleukin-23 production; macrophage activation; detection of lipopolysaccharide; defense response to bacterium; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; positive regulation of nitric-oxide synthase biosynthetic process; negative regulation of osteoclast differentiation; regulation of cytokine secretion; positive regulation of interleukin-12 production; positive regulation of JNK cascade; defense response to Gram-negative bacterium; positive regulation of interleukin-8 production; positive regulation of MHC class II biosynthetic process; negative regulation of interferon-gamma production; lipopolysaccharide-mediated signaling pathway; interferon-gamma production; B cell proliferation during immune response; positive regulation of tumor necrosis factor biosynthetic process; detection of fungus; MyD88-independent toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; positive regulation of interleukin-12 biosynthetic process; negative regulation of interleukin-17 production; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of interleukin-1 production; positive regulation of inflammatory response

Disease: Macular Degeneration, Age-related, 10
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 Research Articles on TLR4    1. Meta-analysis results revealed that the TLR-4 399 C>T polymorphism might increase the risk of colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TLR4 antibodyDiseases associated with anti-TLR4 antibody
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3922 publications with TLR4 and Inflammation
 Necrosis Antibodies  >2552 publications with TLR4 and Necrosis
 Sepsis Antibodies  >792 publications with TLR4 and Sepsis
 Liver Diseases Antibodies  >455 publications with TLR4 and Liver Diseases
 Atherosclerosis Antibodies  >417 publications with TLR4 and Atherosclerosis
 Lung Injury Antibodies  >297 publications with TLR4 and Lung Injury
 Heart Diseases Antibodies  >276 publications with TLR4 and Heart Diseases
 Fibrosis Antibodies  >234 publications with TLR4 and Fibrosis
 Carcinoma Antibodies  >221 publications with TLR4 and Carcinoma
 Kidney Diseases Antibodies  >201 publications with TLR4 and Kidney Diseases
Organs/Tissues associated with anti-TLR4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3929 publications with TLR4 and Blood
 Lung Antibodies  >968 publications with TLR4 and Lung
 Liver Antibodies  >900 publications with TLR4 and Liver
 Bone Antibodies  >870 publications with TLR4 and Bone
 Bone Marrow Antibodies  >729 publications with TLR4 and Bone Marrow
 Vascular Antibodies  >649 publications with TLR4 and Vascular
 Brain Antibodies  >602 publications with TLR4 and Brain
 Intestine Antibodies  >568 publications with TLR4 and Intestine
 Spleen Antibodies  >440 publications with TLR4 and Spleen
 Kidney Antibodies  >438 publications with TLR4 and Kidney
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