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anti-TNFSF4 antibody :: Rabbit anti-Human TNFSF4 Antibody

Scan QR to view Datasheet Catalog #    MBS9387908
Western blot
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNFSF4, Antibody

 Also Known As   

TNFSF4 Antibody

 Product Gene Name   

anti-TNFSF4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL
 OMIM    D90224 mRNA
 3D Structure    ModBase 3D Structure for P23510
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    TNFSF4 Antibody detects endogenous levels of total TNFSF4
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    A synthesized peptide derived from human TNFSF4
 Function    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
 Subcellular Location    Membrane,Single-pass type II membrane protein
 Subunit Structure    Homotrimer
 Similarity    Belongs to the tumor necrosis factor family
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 Preparation and Storage    Store at -20C. Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-TNFSF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TNFSF4 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TNFSF4 antibody    WB 1:500-1:2000
IHC 1:50-1:200
Optimal dilutions/concentrations should be determined by the end user.
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 Western blot of anti-TNFSF4 antibody    Western blot analysis TNFSF4 using COS7 whole cell lysates
anti-TNFSF4 antibody Western blot image
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NCBI/Uniprot data below describe general gene information for TNFSF4. It may not necessarily be applicable to this product.
 NCBI GI #    662033902
 NCBI GeneID    7292
 NCBI Accession #    NP_001284491.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001297562.1 [Other Products]
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 UniProt Primary Accession #    P23510 [Other Products]
 UniProt Secondary Accession #    Q5JZA5; Q8IV74; Q9HCN9 [Other Products]
 UniProt Related Accession #    P23510 [Other Products]
 Molecular Weight    21kDa
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 4 isoform 2
 NCBI Official Synonym Full Names    tumor necrosis factor superfamily member 4
 NCBI Official Symbol    TNFSF4 [Similar Products]
 NCBI Official Synonym Symbols   
GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 4
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 4
 UniProt Synonym Protein Names   
Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF4 [Similar Products]
 UniProt Synonym Gene Names    TXGP1; OX40L [Similar Products]
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 NCBI Summary for TNFSF4    This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for TNFSF4    TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.

Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: cell surface; extracellular space; plasma membrane

Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: acute inflammatory response; defense response to nematode; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of regulatory T cell differentiation; negative regulation of T-helper 1 cell differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell activation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of cell proliferation; positive regulation of immunoglobulin mediated immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of memory T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of T-helper 2 type immune response; regulation of adaptive immune response; regulation of inflammatory response; response to virus; signal transduction; tumor necrosis factor-mediated signaling pathway

Disease: Myocardial Infarction, Susceptibility To
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 Research Articles on TNFSF4    1. Given the discovery cohort, functional data, and importance of TNFSF4 in infection clearance, TNFSF4C may associate with outcomes and warrants future studies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFSF4 antibodyPathways associated with anti-TNFSF4 antibody
 Reference Product  PubMed Publications
 TNFRSF4 antibody  >117 publications with TNFSF4 and TNFRSF4
 FOXP3 antibody  >14 publications with TNFSF4 and FOXP3
 TNFSF8 antibody  >12 publications with TNFSF4 and TNFSF8
 TNFSF9 antibody  >10 publications with TNFSF4 and TNFSF9
 ATM antibody  >2 publications with TNFSF4 and ATM
 CD8A antibody  >1 publications with TNFSF4 and CD8A
 FOS antibody  >1 publications with TNFSF4 and FOS
 OLR1 antibody  >1 publications with TNFSF4 and OLR1
 TNFSF15 antibody  >1 publications with TNFSF4 and TNFSF15
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TNFs Bind Their Physiological Receptors Pathway antibodies  TNFs Bind Their Physiological Receptors Pathway Diagram
 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway antibodies  Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway Diagram
Diseases associated with anti-TNFSF4 antibodyOrgans/Tissues associated with anti-TNFSF4 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >236 publications with TNFSF4 and Necrosis
 Inflammation Antibodies  >58 publications with TNFSF4 and Inflammation
 Lupus Erythematosus, Systemic Antibodies  >43 publications with TNFSF4 and Lupus Erythematosus, Systemic
 Disease Models, Animal Antibodies  >38 publications with TNFSF4 and Disease Models, Animal
 Lung Diseases Antibodies  >22 publications with TNFSF4 and Lung Diseases
 Heart Diseases Antibodies  >18 publications with TNFSF4 and Heart Diseases
 Myocardial Infarction Antibodies  >12 publications with TNFSF4 and Myocardial Infarction
 Neoplasms, Experimental Antibodies  >9 publications with TNFSF4 and Neoplasms, Experimental
 Liver Diseases Antibodies  >7 publications with TNFSF4 and Liver Diseases
 Kidney Diseases Antibodies  >7 publications with TNFSF4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >32 publications with TNFSF4 and Lymph Node
 Lung Antibodies  >26 publications with TNFSF4 and Lung
 Skin Antibodies  >18 publications with TNFSF4 and Skin
 Bone Marrow Antibodies  >14 publications with TNFSF4 and Bone Marrow
 Mixed Antibodies  >10 publications with TNFSF4 and Mixed
 Eye Antibodies  >7 publications with TNFSF4 and Eye
 Liver Antibodies  >6 publications with TNFSF4 and Liver
 Brain Antibodies  >5 publications with TNFSF4 and Brain
 Thymus Antibodies  >2 publications with TNFSF4 and Thymus
 Uterus Antibodies  >1 publications with TNFSF4 and Uterus
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