NP_001129667.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100,408 Da
NCBI Official Full Name
transportin-2 isoform 2
NCBI Official Synonym Full Names
transportin 2
NCBI Protein Information
transportin-2
UniProt Protein Name
Transportin-2
UniProt Synonym Protein Names
Karyopherin beta-2b
UniProt Comments for TNPO2
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus ().
Research Articles on TNPO2
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Products associated with anti-TNPO2 antibody
Diseases associated with anti-TNPO2 antibody
Organs/Tissues associated with anti-TNPO2 antibody
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