NP_001059.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
182,663 Da
NCBI Official Full Name
DNA topoisomerase 2-beta isoform 2
NCBI Official Synonym Full Names
DNA topoisomerase II beta
NCBI Protein Information
DNA topoisomerase 2-beta
UniProt Protein Name
DNA topoisomerase 2-beta
UniProt Synonym Protein Names
DNA topoisomerase II, beta isozyme
NCBI Summary for TOP2B
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
UniProt Comments for TOP2B
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Product References and Citations for anti-TOP2B antibody
René M. Linka, Nucleic Acids Res., May 2007; 10.1093. John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587-5592. Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597-1607. Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301-4308.
Research Articles on TOP2B
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Products associated with anti-TOP2B antibody
Diseases associated with anti-TOP2B antibody
Organs/Tissues associated with anti-TOP2B antibody
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