NP_001269831.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
141,981 Da
NCBI Official Full Name
zinc finger transcription factor Trps1 isoform 2
NCBI Official Synonym Full Names
transcriptional repressor GATA binding 1
NCBI Official Synonym Symbols
NCBI Protein Information
zinc finger transcription factor Trps1
UniProt Protein Name
Zinc finger transcription factor Trps1
UniProt Synonym Protein Names
Tricho-rhino-phalangeal syndrome type I protein; Zinc finger protein GC79
NCBI Summary for TRPS1
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPS1
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Research Articles on TRPS1
Precautions
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Disclaimer
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Products associated with anti-TRPS1 antibody
Diseases associated with anti-TRPS1 antibody
Disease Name |
Pubmed Publications |
Bone Diseases, Developmental Antibodies |
>48 publications with TRPS1 and Bone Diseases, Developmental |
TRICHORHINOPHALANGEAL SYNDROME, TYPE I Antibodies |
>38 publications with TRPS1 and TRICHORHINOPHALANGEAL SYNDROME, TYPE I |
Langer-Giedion Syndrome Antibodies |
>38 publications with TRPS1 and Langer-Giedion Syndrome |
Craniofacial Abnormalities Antibodies |
>29 publications with TRPS1 and Craniofacial Abnormalities |
Congenital Abnormalities Antibodies |
>26 publications with TRPS1 and Congenital Abnormalities |
Abnormalities, Multiple Antibodies |
>17 publications with TRPS1 and Abnormalities, Multiple |
Carcinoma Antibodies |
>8 publications with TRPS1 and Carcinoma |
Prostatic Diseases Antibodies |
>7 publications with TRPS1 and Prostatic Diseases |
Trichorhinophalangeal Syndrome, Type III Antibodies |
>7 publications with TRPS1 and Trichorhinophalangeal Syndrome, Type III |
Genital Diseases, Male Antibodies |
>7 publications with TRPS1 and Genital Diseases, Male |
Organs/Tissues associated with anti-TRPS1 antibody
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