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anti-TTK antibody :: Rabbit anti-Human, mouse TTK (Ab-676) Antibody

Scan QR to view Datasheet Catalog #    MBS001281 anti-TTK antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TTK (Ab-676), Antibody

 Also Known As   

Rabbit TTK (Ab-676) Antibody

 Product Gene Name   

anti-TTK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (80714322..80752244). Location: 6q13-q21
 OMIM    604092
 3D Structure    ModBase 3D Structure for P33981
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-TTK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TTK antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TTK. It may not necessarily be applicable to this product.
 NCBI GI #    262399361
 NCBI GeneID    7272
 NCBI Accession #    NP_001160163.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166691.1 [Other Products]
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 UniProt Primary Accession #    P33981 [Other Products]
 UniProt Secondary Accession #    Q15272; Q5TCS0; Q9BW51; Q9NTM0; A8K8U5; B2RDW2; E1P543 [Other Products]
 UniProt Related Accession #    P33981 [Other Products]
 Molecular Weight    97,072 Da
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 NCBI Official Full Name    dual specificity protein kinase TTK isoform 2
 NCBI Official Synonym Full Names    TTK protein kinase
 NCBI Official Symbol    TTK [Similar Products]
 NCBI Official Synonym Symbols   
ESK; PYT; CT96; MPH1; MPS1; MPS1L1
[Similar Products]
 NCBI Protein Information    dual specificity protein kinase TTK; cancer/testis antigen 96; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase
 UniProt Protein Name    Dual specificity protein kinase TTK
 UniProt Synonym Protein Names   
Phosphotyrosine picked threonine-protein kinase
 Protein Family    Protein tramtrack
 UniProt Gene Name    TTK [Similar Products]
 UniProt Synonym Gene Names    MPS1; MPS1L1; PYT [Similar Products]
 UniProt Entry Name    TTK_HUMAN
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 NCBI Summary for TTK    This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
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 UniProt Comments for TTK    TTK: a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint.

Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, Other; Cancer Testis Antigen (CTA); Protein kinase, dual-specificity (non-receptor); Other group; TTK family

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: membrane; spindle

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; mitotic spindle organization and biogenesis; mitotic cell cycle spindle assembly checkpoint; positive regulation of cell proliferation; spindle organization and biogenesis; chromosome separation
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 Research Articles on TTK    1. These data are consistent with a model in which Aurora B activity relieves a tetratricopeptide repeat domain-dependent inhibitory constraint on MPS1 localization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TTK antibodyPathways associated with anti-TTK antibody
 Reference Product  PubMed Publications
 RPS27 antibody  >1 publications with TTK and RPS27
 E2F4 antibody  >1 publications with TTK and E2F4
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-TTK antibodyOrgans/Tissues associated with anti-TTK antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >56 publications with TTK and Neoplasms
 Carcinoma Antibodies  >19 publications with TTK and Carcinoma
 Brain Diseases Antibodies  >12 publications with TTK and Brain Diseases
 Nervous System Diseases Antibodies  >12 publications with TTK and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with TTK and Disease Models, Animal
 Drug Toxicity Antibodies  >8 publications with TTK and Drug Toxicity
 Breast Neoplasms Antibodies  >7 publications with TTK and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >5 publications with TTK and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >5 publications with TTK and Cell Transformation, Neoplastic
 Colonic Neoplasms Antibodies  >4 publications with TTK and Colonic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >35 publications with TTK and Eye
 Brain Antibodies  >28 publications with TTK and Brain
 Blood Antibodies  >22 publications with TTK and Blood
 Embryonic Tissue Antibodies  >13 publications with TTK and Embryonic Tissue
 Testis Antibodies  >10 publications with TTK and Testis
 Muscle Antibodies  >9 publications with TTK and Muscle
 Heart Antibodies  >9 publications with TTK and Heart
 Bone Antibodies  >6 publications with TTK and Bone
 Vascular Antibodies  >6 publications with TTK and Vascular
 Liver Antibodies  >5 publications with TTK and Liver
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