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anti-Tau antibody :: Rabbit Tau Antibody

Scan QR to view Datasheet Catalog #    MBS851649
Western Blot
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tau, Antibody

 Also Known As   

Tau (Ab-534/217) Antibody

 Product Synonym Names    MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
 Product Gene Name   

anti-Tau antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601104
 3D Structure    ModBase 3D Structure for P10636
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Pathway    Cytoskeletal
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 Other Notes    Small volumes of anti-Tau antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Tau antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Tau antibody   

Western Blot (WB), ELISA (EIA)

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 Western Blot of anti-Tau antibody    Western blot analysis of extracts from rat brain cells, using Tau (Ab-534/217) antibody.
anti-Tau antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for Tau. It may not necessarily be applicable to this product.
 NCBI GI #    294862258
 NCBI GeneID    4137
 NCBI Accession #    NP_001116538.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001123066.3 [Other Products]
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 UniProt Primary Accession #    P10636 [Other Products]
 UniProt Secondary Accession #    P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3 [Other Products]
 UniProt Related Accession #    P10636 [Other Products]
 Molecular Weight    80,941 Da
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 NCBI Official Full Name    microtubule-associated protein tau isoform 6
 NCBI Official Synonym Full Names    microtubule-associated protein tau
 NCBI Official Symbol    MAPT [Similar Products]
 NCBI Official Synonym Symbols   
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
[Similar Products]
 NCBI Protein Information    microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1
 UniProt Protein Name    Microtubule-associated protein tau
 UniProt Synonym Protein Names   
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
 Protein Family    Tautomerase
 UniProt Gene Name    MAPT [Similar Products]
 UniProt Synonym Gene Names    MAPTL; MTBT1; TAU; PHF-tau [Similar Products]
 UniProt Entry Name    TAU_HUMAN
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 NCBI Summary for Tau    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Tau    Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: microtubule; microtubule associated complex; growth cone; axon; tubulin complex; plasma membrane; axoneme; cytosol

Molecular Function: protein binding; enzyme binding; structural constituent of cytoskeleton; microtubule binding; apolipoprotein binding; protein kinase binding; SH3 domain binding

Biological Process: apoptosis; axon extension; positive regulation of microtubule polymerization; positive regulation of axon extension; axon cargo transport; neuron migration; microtubule cytoskeleton organization and biogenesis; regulation of microtubule polymerization; adult walking behavior; mitochondrion transport along microtubule; negative regulation of intracellular transport; generation of neurons; regulation of autophagy; cell structure disassembly during apoptosis

Disease: Supranuclear Palsy, Progressive, 1; Pick Disease Of Brain; Frontotemporal Dementia; Parkinson-dementia Syndrome; Parkinson Disease, Late-onset; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related
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 Research Articles on Tau    1. The results of this study indicate that MAPT haplotypes influence motor features in PD by showing that H1/H1 PD patients are significantly more likely to present a NTD clinical phenotype characterized by widespread pathological degeneration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Tau antibodyDiseases associated with anti-Tau antibody
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1055 publications with Tau and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >953 publications with Tau and Neurodegenerative Diseases
 Brain Diseases Antibodies  >946 publications with Tau and Brain Diseases
 Dementia Antibodies  >866 publications with Tau and Dementia
 Tauopathies Antibodies  >696 publications with Tau and Tauopathies
 Alzheimer Disease Antibodies  >546 publications with Tau and Alzheimer Disease
 Frontotemporal Dementia Antibodies  >362 publications with Tau and Frontotemporal Dementia
 Movement Disorders Antibodies  >254 publications with Tau and Movement Disorders
 Parkinsonian Disorders Antibodies  >195 publications with Tau and Parkinsonian Disorders
 Parkinson Disease Antibodies  >150 publications with Tau and Parkinson Disease
Organs/Tissues associated with anti-Tau antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >728 publications with Tau and Brain
 Nerve Antibodies  >236 publications with Tau and Nerve
 Vascular Antibodies  >26 publications with Tau and Vascular
 Ganglia Antibodies  >25 publications with Tau and Ganglia
 Muscle Antibodies  >24 publications with Tau and Muscle
 Eye Antibodies  >15 publications with Tau and Eye
 Embryonic Tissue Antibodies  >10 publications with Tau and Embryonic Tissue
 Kidney Antibodies  >6 publications with Tau and Kidney
 Bone Antibodies  >5 publications with Tau and Bone
 Prostate Antibodies  >3 publications with Tau and Prostate
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