NP_002151.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
210kDa; 300kDa
NCBI Official Full Name
tenascin
NCBI Official Synonym Full Names
tenascin C
NCBI Official Synonym Symbols
GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225 [Similar Products]
NCBI Protein Information
tenascin
UniProt Protein Name
Tenascin
UniProt Synonym Protein Names
Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C
UniProt Synonym Gene Names
UniProt Entry Name
TENA_HUMAN
NCBI Summary for TNC
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
UniProt Comments for TNC
TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane
Molecular Function: syndecan binding
Biological Process: extracellular matrix organization and biogenesis; osteoblast differentiation; response to wounding
Disease: Deafness, Autosomal Dominant 56
Product References and Citations for anti-TNC antibody
Verstraeten AA, et. al. British Journal of Dermatology, 1992, 127(6):571-4
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Products associated with anti-TNC antibody
Pathways associated with anti-TNC antibody
Diseases associated with anti-TNC antibody
Organs/Tissues associated with anti-TNC antibody
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