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TYMP antibody :: Thymidine Phosphorylase/PD-ECGF Antibody

Scan QR to view Datasheet Catalog #    MBS439921
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thymidine Phosphorylase/PD-ECGF (TYMP), Antibody

★Popular Item★
 Also Known As   

Thymidine Phosphorylase/PD-ECGF (Angiogenesis Marker)

 Product Synonym Names    ECGF; ECGF1; Gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; Tymp
 Product Gene Name   

TYMP antibody

[Similar Products]
 Product Synonym Gene Name    PD-ECGF [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P19971
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    SPM322
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat. Others not known.
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 Specificity    Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
 Cellular Localization    Cytoplasmic and Nuclear
 Hu-chromosome Location    22q13.33
 Positive Control    HUVEC cells. Breast, Bladder, Lung or Kaposi tumors
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of TYMP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TYMP antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin

 Application Notes for TYMP antibody    WB: 0.5-1ug/ml
IP: 0.5-1ug/500ug protein lysate
IHC-F: 1-2ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of TYMP antibody    Formalin-fixed, paraffin-embedded human Placenta stained with Thymidine Phosphorylase / PD-ECGF Monoclonal Antibody (SPM322).
TYMP antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of TYMP antibody    Formalin-fixed, paraffin-embedded human Parathyroid stained with Chromogranin A Monoclonal Antibody (CGA/413)
TYMP antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TYMP. It may not necessarily be applicable to this product.
 NCBI GI #    166158922
 NCBI GeneID    1890
 NCBI Accession #    NP_001107227.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001113755.2 [Other Products]
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 UniProt Primary Accession #    P19971 [Other Products]
 UniProt Secondary Accession #    Q13390; Q8WVB7; A8MW15; H9KVA0 [Other Products]
 UniProt Related Accession #    P19971 [Other Products]
 Molecular Weight    55kDa
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 NCBI Official Full Name    thymidine phosphorylase isoform 1
 NCBI Official Synonym Full Names    thymidine phosphorylase
 NCBI Official Symbol    TYMP [Similar Products]
 NCBI Official Synonym Symbols   
TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF
[Similar Products]
 NCBI Protein Information    thymidine phosphorylase
 UniProt Protein Name    Thymidine phosphorylase
 UniProt Synonym Protein Names   
Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
 UniProt Gene Name    TYMP [Similar Products]
 UniProt Synonym Gene Names    ECGF1; TP; PD-ECGF [Similar Products]
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 NCBI Summary for TYMP    This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
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 UniProt Comments for TYMP    May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
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Product References and Citations for TYMP antibody

   Fox SB, et. al. Journal of Pathology, 1995, 176:183-90. O'Brien TS, et. al. Cancer Research, 1996, 56(20):4799-804. Fox SB, et. al. British Journal of Cancer, 1996, 73:275-80
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 Research Articles on TYMP    1. Data show that thymidine phosphorylase (TYMP) positive patients had higher systemic immune-inflammation index (SII) score.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TYMP antibody Pathways associated with TYMP antibody
 Reference Product  PubMed Publications
 TYMS antibody  >4 publications with TYMP and TYMS
 DPYD antibody  >3 publications with TYMP and DPYD
 UPP1 antibody  >2 publications with TYMP and UPP1
 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
Diseases associated with TYMP antibody Organs/Tissues associated with TYMP antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with TYMP and Nervous System Diseases
 Brain Diseases Antibodies  >20 publications with TYMP and Brain Diseases
 Neoplasms Antibodies  >20 publications with TYMP and Neoplasms
 Carcinoma Antibodies  >7 publications with TYMP and Carcinoma
 Colorectal Neoplasms Antibodies  >7 publications with TYMP and Colorectal Neoplasms
 Mitochondrial neurogastrointestinal encephalopathy syndrome Antibodies  >6 publications with TYMP and Mitochondrial neurogastrointestinal encephalopathy syndrome
 Adenocarcinoma Antibodies  >5 publications with TYMP and Adenocarcinoma
 Diarrhea Antibodies  >4 publications with TYMP and Diarrhea
 Vomiting Antibodies  >4 publications with TYMP and Vomiting
 Pain Antibodies  >3 publications with TYMP and Pain
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >17 publications with TYMP and Muscle
 Blood Antibodies  >12 publications with TYMP and Blood
 Liver Antibodies  >9 publications with TYMP and Liver
 Brain Antibodies  >9 publications with TYMP and Brain
 Skin Antibodies  >4 publications with TYMP and Skin
 Nerve Antibodies  >4 publications with TYMP and Nerve
 Intestine Antibodies  >2 publications with TYMP and Intestine
 Lung Antibodies  >2 publications with TYMP and Lung
 Heart Antibodies  >2 publications with TYMP and Heart
 Eye Antibodies  >2 publications with TYMP and Eye
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