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anti-Tip60 antibody :: Rabbit Tip60 Antibody

Scan QR to view Datasheet Catalog #    MBS853863
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tip60, Antibody

 Also Known As   

Tip60 (Ab-90) Antibody

 Product Synonym Names    60 kDa Tat interactive protein; cPLA(2)-interacting protein; EC 2.3.1.-; EC 2.3.1.48; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; HTATIP; Tat-interactive 60 kDa protein alpha isoform; Tat-interactive protein-60; TI60
 Product Gene Name   

anti-Tip60 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601409
 3D Structure    ModBase 3D Structure for Q92993
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Tip60 (Ab-90) antibody detects endogenous levels of total Tip60 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human Tip60 around the phosphorylation site of serine 90 (P-G-SP-P-E).
 Pathway    Transcription
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-Tip60 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Tip60 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Tip60 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-Tip60 antibody    WB: 1:500~1:1000, ELISA: 1:5000
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 Testing Data of anti-Tip60 antibody    Western blot analysis of extracts from 3T3 cells, treated with starved (24hours), using Tip60 (Ab-90) antibody.
anti-Tip60 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Tip60. It may not necessarily be applicable to this product.
 NCBI GI #    332205931
 NCBI GeneID    10524
 NCBI Accession #    NP_001193762.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206833.1 [Other Products]
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 UniProt Primary Accession #    Q92993 [Other Products]
 UniProt Secondary Accession #    O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7; B4E3C7; C9JL99 [Other Products]
 UniProt Related Accession #    Q92993 [Other Products]
 Molecular Weight    56,292 Da
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 NCBI Official Full Name    histone acetyltransferase KAT5 isoform 4
 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 5
 NCBI Official Symbol    KAT5 [Similar Products]
 NCBI Official Synonym Symbols   
TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT5; K-acetyltransferase 5; cPLA2 interacting protein; cPLA(2)-interacting protein; 60 kDa Tat-interactive protein; Tat interacting protein, 60kDa; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein, 60kDa
 UniProt Protein Name    Histone acetyltransferase KAT5
 UniProt Synonym Protein Names   
60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein
 Protein Family    Histone acetyltransferase
 UniProt Gene Name    KAT5 [Similar Products]
 UniProt Synonym Gene Names    HTATIP; TIP60; Tip60; HIV-1 Tat interactive protein [Similar Products]
 UniProt Entry Name    KAT5_HUMAN
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 NCBI Summary for Tip60    The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Tip60    Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Nucleolus; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; NuA4 histone acetyltransferase complex; perinuclear region of cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; histone acetyltransferase activity; androgen receptor binding; metal ion binding; transcription coactivator activity; protein complex binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; double-strand break repair; regulation of growth; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; response to ionizing radiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of interleukin-2 production
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Product References and Citations for anti-Tip60 antibody

   Kamine J., Virology 216:357-366(1996).
Sheridan A.M., Mol. Cell. Biol. 21:4470-4481(2001).
Legube G., Gene 310:161-168(2003).
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 Research Articles on Tip60    1. that KAT5 RNAi may result in cleaved casp9 upregulation through p38MAPK activation in Gallbladder carcinoma cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tip60 antibodyPathways associated with anti-Tip60 antibody
 Reference Product  PubMed Publications
 ATM antibody  >23 publications with Tip60 and ATM
 APBB1 antibody  >17 publications with Tip60 and APBB1
 MYC antibody  >13 publications with Tip60 and MYC
 MDM2 antibody  >11 publications with Tip60 and MDM2
 TRRAP antibody  >10 publications with Tip60 and TRRAP
 RUVBL1 antibody  >7 publications with Tip60 and RUVBL1
 TP53 antibody  >6 publications with Tip60 and TP53
 RUVBL2 antibody  >5 publications with Tip60 and RUVBL2
 EP400 antibody  >4 publications with Tip60 and EP400
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL-9 Signaling Pathway antibodies  IL-9 Signaling Pathway Diagram
Diseases associated with anti-Tip60 antibodyOrgans/Tissues associated with anti-Tip60 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >11 publications with Tip60 and Prostatic Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with Tip60 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >4 publications with Tip60 and Breast Neoplasms
 Lung Neoplasms Antibodies  >4 publications with Tip60 and Lung Neoplasms
 Necrosis Antibodies  >3 publications with Tip60 and Necrosis
 Adenocarcinoma Antibodies  >3 publications with Tip60 and Adenocarcinoma
 Liver Neoplasms Antibodies  >2 publications with Tip60 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with Tip60 and Carcinoma, Hepatocellular
 Bone Marrow Diseases Antibodies  >1 publications with Tip60 and Bone Marrow Diseases
 Glioblastoma Antibodies  >1 publications with Tip60 and Glioblastoma
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >15 publications with Tip60 and Prostate
 Thyroid Antibodies  >13 publications with Tip60 and Thyroid
 Kidney Antibodies  >10 publications with Tip60 and Kidney
 Blood Antibodies  >7 publications with Tip60 and Blood
 Lung Antibodies  >7 publications with Tip60 and Lung
 Brain Antibodies  >7 publications with Tip60 and Brain
 Muscle Antibodies  >5 publications with Tip60 and Muscle
 Liver Antibodies  >4 publications with Tip60 and Liver
 Lymph Antibodies  >3 publications with Tip60 and Lymph
 Heart Antibodies  >3 publications with Tip60 and Heart
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