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anti-Trk B antibody :: Rabbit Trk B Antibody

Scan QR to view Datasheet Catalog #    MBS8508065 anti-Trk B antibody
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Trk B, Antibody

 Also Known As   

Trk B Antibody

 Product Synonym Names    EC 2.7.10.1 Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase GP145-TrkB Trk-B
 Product Gene Name   

anti-Trk B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613886
 3D Structure    ModBase 3D Structure for Q16620
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Other Notes    Small volumes of anti-Trk B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Trk B antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for Trk B. It may not necessarily be applicable to this product.
 NCBI GI #    2497560
 NCBI GeneID    4915
 NCBI Accession #    Q16620.1 [Other Products]
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 UniProt Primary Accession #    Q16620 [Other Products]
 UniProt Secondary Accession #    Q16675; Q59GJ1; Q8WXJ5; Q8WXJ6; Q8WXJ7; B1ANZ4; B4DFV9 [Other Products]
 UniProt Related Accession #    Q16620 [Other Products]
 Molecular Weight    35,332 Da
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 NCBI Official Full Name    BDNF/NT-3 growth factors receptor
 NCBI Official Synonym Full Names    neurotrophic tyrosine kinase, receptor, type 2
 NCBI Official Symbol    NTRK2 [Similar Products]
 NCBI Official Synonym Symbols   
TRKB; trk-B; GP145-TrkB
[Similar Products]
 NCBI Protein Information    BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B
 UniProt Protein Name    BDNF/NT-3 growth factors receptor
 UniProt Synonym Protein Names   
GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
 UniProt Gene Name    NTRK2 [Similar Products]
 UniProt Synonym Gene Names    TRKB; Trk-B [Similar Products]
 UniProt Entry Name    NTRK2_HUMAN
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 NCBI Summary for Trk B    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for Trk B    TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Trk family

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: postsynaptic membrane; cell surface; growth cone; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; presynaptic active zone; terminal button; excitatory synapse; endosome membrane; perikaryon; cytosol; receptor complex

Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding

Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; neuron migration; regulation of neurotransmitter secretion; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; vasculogenesis; inflammatory response; neuromuscular junction development; aging; central nervous system neuron development; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; long-term memory; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Obesity, Hyperphagia, And Developmental Delay
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 Research Articles on Trk B    1. BDNF activates TrkB, leading to receptor internalization and degradation, in contrast, 7,8-DHF-triggered TrkB phosphorylation and the internalized receptors are not degraded.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Trk B antibodyPathways associated with anti-Trk B antibody
 Reference Product  PubMed Publications
 BDNF antibody  >2613 publications with Trk B and BDNF
 NGFR antibody  >37 publications with Trk B and NGFR
 SHC1 antibody  >15 publications with Trk B and SHC1
 NTF4 antibody  >7 publications with Trk B and NTF4
 SHC3 antibody  >4 publications with Trk B and SHC3
 NTF3 antibody  >4 publications with Trk B and NTF3
 SH2B1 antibody  >3 publications with Trk B and SH2B1
 SHC2 antibody  >3 publications with Trk B and SHC2
 GIPC1 antibody  >2 publications with Trk B and GIPC1
 PLCG1 antibody  >1 publications with Trk B and PLCG1
 Products by Pathway  Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 NGF-independant TRKA Activation Pathway antibodies  NGF-independant TRKA Activation Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
Diseases associated with anti-Trk B antibodyOrgans/Tissues associated with anti-Trk B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >587 publications with Trk B and Nervous System Diseases
 Disease Models, Animal Antibodies  >244 publications with Trk B and Disease Models, Animal
 Neuroblastoma Antibodies  >139 publications with Trk B and Neuroblastoma
 Cardiovascular Diseases Antibodies  >117 publications with Trk B and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >102 publications with Trk B and Nerve Degeneration
 Pain Antibodies  >98 publications with Trk B and Pain
 Inflammation Antibodies  >86 publications with Trk B and Inflammation
 Memory Disorders Antibodies  >72 publications with Trk B and Memory Disorders
 Seizures Antibodies  >60 publications with Trk B and Seizures
 Learning Disorders Antibodies  >60 publications with Trk B and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2803 publications with Trk B and Brain
 Nerve Antibodies  >1634 publications with Trk B and Nerve
 Eye Antibodies  >162 publications with Trk B and Eye
 Muscle Antibodies  >150 publications with Trk B and Muscle
 Embryonic Tissue Antibodies  >127 publications with Trk B and Embryonic Tissue
 Ear Antibodies  >67 publications with Trk B and Ear
 Bone Antibodies  >64 publications with Trk B and Bone
 Lung Antibodies  >64 publications with Trk B and Lung
 Mouth Antibodies  >51 publications with Trk B and Mouth
 Ovary Antibodies  >33 publications with Trk B and Ovary
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