NP_001008225.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2
NCBI Official Synonym Full Names
uveal autoantigen with coiled-coil domains and ankyrin repeats
NCBI Official Synonym Symbols
NCBI Protein Information
uveal autoantigen with coiled-coil domains and ankyrin repeats
UniProt Protein Name
Uveal autoantigen with coiled-coil domains and ankyrin repeats
UniProt Synonym Gene Names
UniProt Entry Name
UACA_HUMAN
UniProt Comments for UACA
UACA: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 15q22-q24
Cellular Component: cytoplasm; mitochondrion; nucleus
Molecular Function: protein binding
Product References and Citations for anti-UACA antibody
Yamada, K., et al. 2001. Identification of a novel autoantigen UACA in patients with panuveitis. Biochem. Biophys. Res. Commun. 280: 1169-1176. Ohkura, T., et al. 2004. Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves disease. Biochem. Biophys. Res. Commun. 321: 432-440
Research Articles on UACA
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Products associated with anti-UACA antibody
Diseases associated with anti-UACA antibody
Organs/Tissues associated with anti-UACA antibody
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