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anti-UBASH3A antibody :: Rabbit anti-Human UBASH3A Antibody

Scan QR to view Datasheet Catalog #    MBS003360 anti-UBASH3A antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBASH3A, Antibody

 Also Known As   

Rabbit UBASH3A Antibody

 Product Gene Name   

anti-UBASH3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (43823971..43867790). Location: 21q22.3
 OMIM    605736
 3D Structure    ModBase 3D Structure for P57075
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-UBASH3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-UBASH3A antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for UBASH3A. It may not necessarily be applicable to this product.
 NCBI GI #    49640014
 NCBI GeneID    53347
 NCBI Accession #    NP_001001895.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001895.2 [Other Products]
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 UniProt Primary Accession #    P57075 [Other Products]
 UniProt Secondary Accession #    Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; G5E9E4 [Other Products]
 UniProt Related Accession #    P57075 [Other Products]
 Molecular Weight    74,123 Da
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 NCBI Official Full Name    ubiquitin-associated and SH3 domain-containing protein A isoform 2
 NCBI Official Synonym Full Names    ubiquitin associated and SH3 domain containing A
 NCBI Official Symbol    UBASH3A [Similar Products]
 NCBI Official Synonym Symbols   
TULA; CLIP4; STS-2; TULA-1
[Similar Products]
 NCBI Protein Information    ubiquitin-associated and SH3 domain-containing protein A; T-cell ubiquitin ligand 1; cbl-interacting protein 4; T-cell ubiquitin ligand protein; suppressor of T-cell receptor signaling 2
 UniProt Protein Name    Ubiquitin-associated and SH3 domain-containing protein A
 UniProt Synonym Protein Names   
Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1
 Protein Family    Ubiquitin-associated and SH3 domain-containing protein
 UniProt Gene Name    UBASH3A [Similar Products]
 UniProt Synonym Gene Names    STS2; CLIP4; STS-2; TULA-1 [Similar Products]
 UniProt Entry Name    UBS3A_HUMAN
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 NCBI Summary for UBASH3A    This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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 UniProt Comments for UBASH3A    STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleus; cytosol

Biological Process: negative regulation of T cell receptor signaling pathway; regulation of cytokine production
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 Research Articles on UBASH3A    1. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-UBASH3A antibodyOrgans/Tissues associated with anti-UBASH3A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with UBASH3A and Nervous System Diseases
 Neoplasms Antibodies  >1 publications with UBASH3A and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with UBASH3A and Blood
 Thyroid Antibodies  >1 publications with UBASH3A and Thyroid
 Spleen Antibodies  >1 publications with UBASH3A and Spleen
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