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anti-VAV1 antibody :: Rabbit VAV1 (Phospho-Tyr174) Antibody

Scan QR to view Datasheet Catalog #    MBS000030 anti-VAV1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VAV1 (Phospho-Tyr174), Antibody

 Also Known As   

Rabbit VAV1 (Phospho-Tyr174) Antibody

 Product Gene Name   

anti-VAV1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (6772679..6857377). Location: 19p13.2
 OMIM    164875
 3D Structure    ModBase 3D Structure for P15498
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-VAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VAV1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for VAV1. It may not necessarily be applicable to this product.
 NCBI GI #    7108367
 NCBI GeneID    7409
 NCBI Accession #    NP_005419.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005428.3 [Other Products]
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 UniProt Primary Accession #    P15498 [Other Products]
 UniProt Secondary Accession #    Q15860 [Other Products]
 UniProt Related Accession #    P15498 [Other Products]
 Molecular Weight    98,314 Da
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 NCBI Official Full Name    proto-oncogene vav isoform 1
 NCBI Official Synonym Full Names    vav 1 guanine nucleotide exchange factor
 NCBI Official Symbol    VAV1 [Similar Products]
 NCBI Official Synonym Symbols   
VAV
[Similar Products]
 NCBI Protein Information    proto-oncogene vav; vav 1 oncogene
 UniProt Protein Name    Proto-oncogene vav
 Protein Family    Proto-oncogene
 UniProt Gene Name    VAV1 [Similar Products]
 UniProt Synonym Gene Names    VAV [Similar Products]
 UniProt Entry Name    VAV_HUMAN
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 NCBI Summary for VAV1    This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
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 UniProt Comments for VAV1    Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subunit structure: May interact with CCPG1

By similarity. Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK

By similarity. Interacts with THEMIS2. Interacts with HCK

By similarity. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54

By similarity. Ref.8 Ref.9 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.20

Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types.

Domain: The DH domain is involved in interaction with CCPG1

By similarity.

Post-translational modification: Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS)

By similarity. Phosphorylated by FYN. Ref.12

Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet.

Sequence similarities: Contains 1 CH (calponin-homology) domain.Contains 1 DH (DBL-homology) domain.Contains 1 PH domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 SH2 domain.Contains 2 SH3 domains.

Sequence caution: The sequence CAA34383.1 differs from that shown. Reason: Frameshift at positions 322 and 355.
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 Research Articles on VAV1    1. study provides evidence the large GTPase Dyn2 regulates the small GTPase Rac1 to potentiate invasive migration of pancreatic tumor cells; Dyn2 plays an essential role in regulating Rac1-mediated pancreatic tumor cell migration through modulation of the Rac1 activator Vav1 via a direct interaction
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VAV1 antibodyPathways associated with anti-VAV1 antibody
 Reference Product  PubMed Publications
 RAC1 antibody  >101 publications with VAV1 and RAC1
 CDC42 antibody  >57 publications with VAV1 and CDC42
 SYK antibody  >55 publications with VAV1 and SYK
 LCK antibody  >47 publications with VAV1 and LCK
 ZAP70 antibody  >46 publications with VAV1 and ZAP70
 GRB2 antibody  >45 publications with VAV1 and GRB2
 LAT antibody  >35 publications with VAV1 and LAT
 CBL antibody  >35 publications with VAV1 and CBL
 BCR antibody  >31 publications with VAV1 and BCR
 FYN antibody  >30 publications with VAV1 and FYN
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
Diseases associated with anti-VAV1 antibodyOrgans/Tissues associated with anti-VAV1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >95 publications with VAV1 and Neoplasms
 Immune System Diseases Antibodies  >61 publications with VAV1 and Immune System Diseases
 Leukemia Antibodies  >47 publications with VAV1 and Leukemia
 Inflammation Antibodies  >19 publications with VAV1 and Inflammation
 Carcinoma Antibodies  >16 publications with VAV1 and Carcinoma
 Cardiovascular Diseases Antibodies  >12 publications with VAV1 and Cardiovascular Diseases
 Necrosis Antibodies  >11 publications with VAV1 and Necrosis
 Adenocarcinoma Antibodies  >10 publications with VAV1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >6 publications with VAV1 and Lung Neoplasms
 Congenital Abnormalities Antibodies  >4 publications with VAV1 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >369 publications with VAV1 and Blood
 Bone Antibodies  >37 publications with VAV1 and Bone
 Bone Marrow Antibodies  >33 publications with VAV1 and Bone Marrow
 Thymus Antibodies  >23 publications with VAV1 and Thymus
 Spleen Antibodies  >16 publications with VAV1 and Spleen
 Lung Antibodies  >14 publications with VAV1 and Lung
 Lymph Node Antibodies  >11 publications with VAV1 and Lymph Node
 Lymph Antibodies  >8 publications with VAV1 and Lymph
 Brain Antibodies  >5 publications with VAV1 and Brain
 Ovary Antibodies  >3 publications with VAV1 and Ovary
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