NP_001127870.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,289 Da
NCBI Official Full Name
guanine nucleotide exchange factor VAV2 isoform 1
NCBI Official Synonym Full Names
vav 2 guanine nucleotide exchange factor
NCBI Official Synonym Symbols
NCBI Protein Information
guanine nucleotide exchange factor VAV2; vav 2 oncogene
UniProt Protein Name
Guanine nucleotide exchange factor VAV2
UniProt Synonym Gene Names
UniProt Entry Name
VAV2_HUMAN
NCBI Summary for VAV2
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for VAV2
VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.
Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; metal ion binding; guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding
Biological Process: lamellipodium biogenesis; axon guidance; platelet activation; cell migration; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; signal transduction; regulation of small GTPase mediated signal transduction; regulation of gene expression; small GTPase mediated signal transduction; regulation of blood coagulation; ephrin receptor signaling pathway; innate immune response; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway
Research Articles on VAV2
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Products associated with anti-VAV2 antibody
Pathways associated with anti-VAV2 antibody
Diseases associated with anti-VAV2 antibody
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