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anti-CDH5 antibody :: Rabbit anti-Human, mouse VE-Cadherin (Ab-731) Antibody

Scan QR to view Datasheet Catalog #    MBS001278 anti-CDH5 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VE-Cadherin (Ab-731) (CDH5), Antibody

 Also Known As   

Rabbit VE-Cadherin (Ab-731) Antibody

 Product Gene Name   

anti-CDH5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (66400525..66438689). Location: 16q22.1
 OMIM    601120
 3D Structure    ModBase 3D Structure for P33151
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CDH5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDH5 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CDH5. It may not necessarily be applicable to this product.
 NCBI GI #    166362713
 NCBI GeneID    1003
 NCBI Accession #    NP_001786.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001795.3 [Other Products]
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 UniProt Primary Accession #    P33151 [Other Products]
 UniProt Related Accession #    P33151 [Other Products]
 Molecular Weight    87,528 Da [Similar Products]
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 NCBI Official Full Name    cadherin-5 preproprotein
 NCBI Official Synonym Full Names    cadherin 5, type 2 (vascular endothelium)
 NCBI Official Symbol    CDH5 [Similar Products]
 NCBI Official Synonym Symbols   
7B4; CD144
[Similar Products]
 NCBI Protein Information    cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium)
 UniProt Protein Name    Cadherin-5
 UniProt Synonym Protein Names   
7B4 antigen; Vascular endothelial cadherin
 Protein Family    Cadherin
 UniProt Gene Name    CDH5 [Similar Products]
 UniProt Synonym Gene Names    VE-cadherin [Similar Products]
 UniProt Entry Name    CADH5_HUMAN
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 NCBI Summary for CDH5    This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDH5    CDH5: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: adherens junction; tight junction; membrane; plasma membrane; integral to membrane; intercellular junction; cell junction

Molecular Function: protein binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; receptor binding

Biological Process: intercellular junction assembly and maintenance; negative regulation of cell proliferation; homophilic cell adhesion; vascular endothelial growth factor receptor signaling pathway; blood vessel maturation
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 Research Articles on CDH5    1. The effects of mesenchymal stem cells on vascular network formation are abrogated by disruption of the VE-Cadherin/beta-catenin pathway in endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH5 antibodyPathways associated with anti-CDH5 antibody
 Reference Product  PubMed Publications
 KDR antibody  >4 publications with CDH5 and KDR
 VIM antibody  >2 publications with CDH5 and VIM
 DSP antibody  >1 publications with CDH5 and DSP
 CTNNB1 antibody  >1 publications with CDH5 and CTNNB1
 CTNNA1 antibody  >1 publications with CDH5 and CTNNA1
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 S1P2 Pathway antibodies  S1P2 Pathway Diagram
 Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway antibodies  Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway Diagram
Diseases associated with anti-CDH5 antibodyOrgans/Tissues associated with anti-CDH5 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with CDH5 and Neoplasms
 Cardiovascular Diseases Antibodies  >6 publications with CDH5 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >3 publications with CDH5 and Breast Neoplasms
 Myocardial Infarction Antibodies  >2 publications with CDH5 and Myocardial Infarction
 Hemorrhage Antibodies  >2 publications with CDH5 and Hemorrhage
 Necrosis Antibodies  >2 publications with CDH5 and Necrosis
 Inflammation Antibodies  >2 publications with CDH5 and Inflammation
 Neovascularization, Pathologic Antibodies  >2 publications with CDH5 and Neovascularization, Pathologic
 Brain Diseases Antibodies  >2 publications with CDH5 and Brain Diseases
 Heart Diseases Antibodies  >2 publications with CDH5 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >21 publications with CDH5 and Vascular
 Embryonic Tissue Antibodies  >10 publications with CDH5 and Embryonic Tissue
 Brain Antibodies  >6 publications with CDH5 and Brain
 Heart Antibodies  >4 publications with CDH5 and Heart
 Kidney Antibodies  >4 publications with CDH5 and Kidney
 Placenta Antibodies  >4 publications with CDH5 and Placenta
 Lung Antibodies  >3 publications with CDH5 and Lung
 Muscle Antibodies  >3 publications with CDH5 and Muscle
 Umbilical Cord Antibodies  >3 publications with CDH5 and Umbilical Cord
 Bone Antibodies  >3 publications with CDH5 and Bone
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