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anti-VEGFR2 antibody :: Rabbit VEGFR2 Antibody

Scan QR to view Datasheet Catalog #    MBS852192
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VEGFR2, Antibody

★Popular Item★
 Also Known As   

VEGFR2 (Phospho-Tyr1214) Antibody

 Product Synonym Names    EC 2.7.10.1; FLK1; KDR; kinase insert domain receptor; protein-tyrosine kinase receptor Flk-1; vascular endothelial growth factor receptor 2; VGFR2; VGR2
 Product Gene Name   

anti-VEGFR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 602089
 3D Structure    ModBase 3D Structure for P35968
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    VEGFR2 (Phospho-Tyr1214) antibody detects endogenous levels of VEGFR2 only when phosphorylated at tyrosine 1214.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1214 (F-H-YP-D-N).
 All Sites    Human: Tyr1214; Mouse: Tyr1212; Rat: Tyr1210
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-VEGFR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VEGFR2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-VEGFR2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-VEGFR2 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:10000
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 Testing Data of anti-VEGFR2 antibody    anti-VEGFR2 antibody Testing Data image
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 Testing Data #2 of anti-VEGFR2 antibody    P-peptide - +
Western blot analysis of extracts from HepG2 cells, treated with Na3VO4 (0.3nM, 40mins), using VEGFR2 (Phospho-Tyr1214) antibody.
Immunohistochemical analysis of paraffin-embedded breast carcinoma, using VEGFR2 (Phospho-Tyr1214) Antibody.
anti-VEGFR2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for VEGFR2. It may not necessarily be applicable to this product.
 NCBI GI #    11321597
 NCBI GeneID    3791
 NCBI Accession #    NP_002244.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002253.2 [Other Products]
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 UniProt Primary Accession #    P35968 [Other Products]
 UniProt Secondary Accession #    O60723; Q14178; A2RRS0; B5A925; C5IFA0 [Other Products]
 UniProt Related Accession #    P35968 [Other Products]
 Molecular Weight    79,634 Da
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 NCBI Official Full Name    vascular endothelial growth factor receptor 2
 NCBI Official Synonym Full Names    kinase insert domain receptor (a type III receptor tyrosine kinase)
 NCBI Official Symbol    KDR [Similar Products]
 NCBI Official Synonym Symbols   
FLK1; CD309; VEGFR; VEGFR2
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor
 UniProt Protein Name    Vascular endothelial growth factor receptor 2
 UniProt Synonym Protein Names   
Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309
 UniProt Gene Name    KDR [Similar Products]
 UniProt Synonym Gene Names    FLK1; VEGFR2; VEGFR-2; FLK-1; KDR [Similar Products]
 UniProt Entry Name    VGFR2_HUMAN
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 NCBI Summary for VEGFR2    Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
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 UniProt Comments for VEGFR2    VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.

Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Chromosomal Location of Human Ortholog: 4q11-q12

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; cytoplasmic membrane-bound vesicle; early endosome; plasma membrane; extracellular region; cell junction; nucleus; endosome; lipid raft; external side of plasma membrane

Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; protein-tyrosine kinase activity; Hsp90 protein binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell migration

Disease: Hemangioma, Capillary Infantile
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Product References and Citations for anti-VEGFR2 antibody

   Yin L.Y., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Yu Y., Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Terman B.I., Oncogene 6:1677-1683(1991).
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 Research Articles on VEGFR2    1. There is evidence of increased placental angiogenesis in late-onset pre-eclampsia and early-onset pre-eclampsia that is associated with differential activation of VEGFR2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VEGFR2 antibodyPathways associated with anti-VEGFR2 antibody
 Reference Product  PubMed Publications
 VEGFA antibody  >266 publications with VEGFR2 and VEGFA
 SRC antibody  >56 publications with VEGFR2 and SRC
 FLT4 antibody  >45 publications with VEGFR2 and FLT4
 VEGFC antibody  >33 publications with VEGFR2 and VEGFC
 NRP1 antibody  >16 publications with VEGFR2 and NRP1
 FIGF antibody  >5 publications with VEGFR2 and FIGF
 PTPN6 antibody  >5 publications with VEGFR2 and PTPN6
 SHC1 antibody  >4 publications with VEGFR2 and SHC1
 CDH5 antibody  >4 publications with VEGFR2 and CDH5
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-VEGFR2 antibodyOrgans/Tissues associated with anti-VEGFR2 antibody
 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >386 publications with VEGFR2 and Neovascularization, Pathologic
 Cardiovascular Diseases Antibodies  >316 publications with VEGFR2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >155 publications with VEGFR2 and Heart Diseases
 Myocardial Ischemia Antibodies  >144 publications with VEGFR2 and Myocardial Ischemia
 Adenocarcinoma Antibodies  >122 publications with VEGFR2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >105 publications with VEGFR2 and Neoplasms, Experimental
 Inflammation Antibodies  >93 publications with VEGFR2 and Inflammation
 Breast Neoplasms Antibodies  >91 publications with VEGFR2 and Breast Neoplasms
 Hypertension Antibodies  >80 publications with VEGFR2 and Hypertension
 Atherosclerosis Antibodies  >79 publications with VEGFR2 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2095 publications with VEGFR2 and Vascular
 Bone Antibodies  >254 publications with VEGFR2 and Bone
 Embryonic Tissue Antibodies  >247 publications with VEGFR2 and Embryonic Tissue
 Muscle Antibodies  >225 publications with VEGFR2 and Muscle
 Heart Antibodies  >196 publications with VEGFR2 and Heart
 Liver Antibodies  >177 publications with VEGFR2 and Liver
 Lung Antibodies  >176 publications with VEGFR2 and Lung
 Placenta Antibodies  >118 publications with VEGFR2 and Placenta
 Brain Antibodies  >107 publications with VEGFR2 and Brain
 Kidney Antibodies  >95 publications with VEGFR2 and Kidney
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