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anti-VEGFR2 antibody :: VEGFR2 Antibody

Scan QR to view Datasheet Catalog #    MBS857447
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VEGFR2, Antibody

 Also Known As   

VEGFR2 (Ab-1175) Antibody

 Product Gene Name   

anti-VEGFR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191306
 3D Structure    ModBase 3D Structure for P35968
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    VEGFR2 (Ab-1175) antibody detects endogenous levels of total VEGFR2 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1175 (K-D-YP-I-V).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-VEGFR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VEGFR2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-VEGFR2 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-VEGFR2 antibody    IHC: 1:50~1:100
IF: 1:100~1:200
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 Immunohistochemistry (IHC) of anti-VEGFR2 antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using VEGFR2 (Ab-1175) antibody.
anti-VEGFR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VEGFR2. It may not necessarily be applicable to this product.
 NCBI GI #    11321597
 NCBI GeneID    3791
 NCBI Accession #    NP_002244.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002253.3 [Other Products]
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 UniProt Primary Accession #    P35968 [Other Products]
 UniProt Secondary Accession #    O60723; Q14178; A2RRS0; B5A925; C5IFA0 [Other Products]
 UniProt Related Accession #    P35968 [Other Products]
 Molecular Weight    79,634 Da
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 NCBI Official Full Name    vascular endothelial growth factor receptor 2
 NCBI Official Synonym Full Names    kinase insert domain receptor
 NCBI Official Symbol    KDR [Similar Products]
 NCBI Official Synonym Symbols   
FLK1; CD309; VEGFR; VEGFR2
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 2
 UniProt Protein Name    Vascular endothelial growth factor receptor 2
 UniProt Synonym Protein Names   
Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309
 UniProt Gene Name    KDR [Similar Products]
 UniProt Synonym Gene Names    FLK1; VEGFR2; VEGFR-2; FLK-1; KDR [Similar Products]
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 NCBI Summary for VEGFR2    Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
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 UniProt Comments for VEGFR2    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
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Product References and Citations for anti-VEGFR2 antibody

   Lamalice L, et al. (2004). Oncogene.23(2): 434-445. Takahashi T, et al. (2001). EMBO J.20(11): 2768-2778.
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 Research Articles on VEGFR2    1. Increased expression of VEGFR2 correlated with differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VEGFR2 antibodyPathways associated with anti-VEGFR2 antibody
 Reference Product  PubMed Publications
 VEGFA antibody  >225 publications with VEGFR2 and VEGFA
 FLT1 antibody  >173 publications with VEGFR2 and FLT1
 SRC antibody  >54 publications with VEGFR2 and SRC
 FLT4 antibody  >37 publications with VEGFR2 and FLT4
 VEGFC antibody  >29 publications with VEGFR2 and VEGFC
 NRP1 antibody  >15 publications with VEGFR2 and NRP1
 COL18A1 antibody  >10 publications with VEGFR2 and COL18A1
 GRB2 antibody  >6 publications with VEGFR2 and GRB2
 CRK antibody  >5 publications with VEGFR2 and CRK
 CTNNB1 antibody  >5 publications with VEGFR2 and CTNNB1
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
Diseases associated with anti-VEGFR2 antibodyOrgans/Tissues associated with anti-VEGFR2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >623 publications with VEGFR2 and Neoplasms
 Neovascularization, Pathologic Antibodies  >369 publications with VEGFR2 and Neovascularization, Pathologic
 Heart Diseases Antibodies  >138 publications with VEGFR2 and Heart Diseases
 Myocardial Ischemia Antibodies  >127 publications with VEGFR2 and Myocardial Ischemia
 Adenocarcinoma Antibodies  >110 publications with VEGFR2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >102 publications with VEGFR2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >85 publications with VEGFR2 and Breast Neoplasms
 Inflammation Antibodies  >83 publications with VEGFR2 and Inflammation
 Drug Toxicity Antibodies  >81 publications with VEGFR2 and Drug Toxicity
 Atherosclerosis Antibodies  >73 publications with VEGFR2 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1955 publications with VEGFR2 and Vascular
 Embryonic Tissue Antibodies  >239 publications with VEGFR2 and Embryonic Tissue
 Bone Antibodies  >231 publications with VEGFR2 and Bone
 Muscle Antibodies  >211 publications with VEGFR2 and Muscle
 Heart Antibodies  >174 publications with VEGFR2 and Heart
 Liver Antibodies  >165 publications with VEGFR2 and Liver
 Lung Antibodies  >161 publications with VEGFR2 and Lung
 Placenta Antibodies  >110 publications with VEGFR2 and Placenta
 Brain Antibodies  >98 publications with VEGFR2 and Brain
 Kidney Antibodies  >88 publications with VEGFR2 and Kidney
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