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anti-VDR antibody :: Rabbit Vitamin D3 Receptor Antibody

Scan QR to view Datasheet Catalog #    MBS854516
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vitamin D3 Receptor (VDR), Antibody

 Also Known As   

Vitamin D3 Receptor (Phospho-Ser51) Antibody

 Product Synonym Names    1; 25-dihydroxyvitamin D3 receptor; NR1I1; vitamin D receptor; vitamin D3 receptor
 Product Gene Name   

anti-VDR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 607948
 3D Structure    ModBase 3D Structure for P11473
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Vitamin D3 Receptor (Phospho-Ser51) antibody detects endogenous levels of Vitamin D3 Receptor only when phosphorylated at serine 51.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-SP-M-K).
 All Sites    Human: Ser51; Mouse: Ser51; Rat: Ser51
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-VDR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VDR antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-VDR antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-VDR antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-VDR antibody    Western blot analysis of extracts from COLO cells, treated with Insulin (0.01U/ml, 15mins), using Vitamin D3 Receptor (Phospho-Ser51) antibody.
anti-VDR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for VDR. It may not necessarily be applicable to this product.
 NCBI GI #    4507883
 NCBI GeneID    7421
 NCBI Accession #    NP_000367.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000376.2 [Other Products]
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 UniProt Primary Accession #    P11473 [Other Products]
 UniProt Secondary Accession #    Q5PSV3; B2R5Q1; G3V1V9 [Other Products]
 UniProt Related Accession #    P11473 [Other Products]
 Molecular Weight    53,883 Da [Similar Products]
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 NCBI Official Full Name    vitamin D3 receptor isoform VDRA
 NCBI Official Synonym Full Names    vitamin D (1,25- dihydroxyvitamin D3) receptor
 NCBI Official Symbol    VDR [Similar Products]
 NCBI Official Synonym Symbols   
NR1I1; PPP1R163
[Similar Products]
 NCBI Protein Information    vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; vitamin D nuclear receptor variant 1; nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163
 UniProt Protein Name    Vitamin D3 receptor
 UniProt Synonym Protein Names   
1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
 Protein Family    Vitamin D3 receptor
 UniProt Gene Name    VDR [Similar Products]
 UniProt Synonym Gene Names    NR1I1; VDR [Similar Products]
 UniProt Entry Name    VDR_HUMAN
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 NCBI Summary for VDR    This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
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 UniProt Comments for VDR    VDR: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.11

Cellular Component: nucleoplasm; nucleus; receptor complex

Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D3 receptor activity; transcription factor activity

Biological Process: lactation; transcription initiation from RNA polymerase II promoter; positive regulation of apoptosis involved in mammary gland involution; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; decidualization; signal transduction; intestinal absorption; cellular calcium ion homeostasis; negative regulation of cell proliferation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent; skeletal development; positive regulation of keratinocyte differentiation

Disease: Vitamin D-dependent Rickets, Type 2a; Osteoporosis
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Product References and Citations for anti-VDR antibody

   Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H., Biochim. Biophys. Acta 1132:103-108(1992).
Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).
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 Research Articles on VDR    1. cumulative effect of TaqI polymorphism in VDR was significantly associated with primary biliary cirrhosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VDR antibodyPathways associated with anti-VDR antibody
 Reference Product  PubMed Publications
 SRC antibody  >87 publications with VDR and SRC
 NCOA1 antibody  >39 publications with VDR and NCOA1
 MED1 antibody  >31 publications with VDR and MED1
 NCOR1 antibody  >28 publications with VDR and NCOR1
 NCOA2 antibody  >12 publications with VDR and NCOA2
 RXRA antibody  >12 publications with VDR and RXRA
 NCOA3 antibody  >10 publications with VDR and NCOA3
 CREBBP antibody  >6 publications with VDR and CREBBP
 EP300 antibody  >4 publications with VDR and EP300
 SNW1 antibody  >4 publications with VDR and SNW1
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with anti-VDR antibodyOrgans/Tissues associated with anti-VDR antibody
 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >423 publications with VDR and Osteoporosis
 Vitamin D Deficiency Antibodies  >393 publications with VDR and Vitamin D Deficiency
 Kidney Diseases Antibodies  >310 publications with VDR and Kidney Diseases
 Breast Neoplasms Antibodies  >218 publications with VDR and Breast Neoplasms
 Rickets Antibodies  >204 publications with VDR and Rickets
 Inflammation Antibodies  >199 publications with VDR and Inflammation
 Cardiovascular Diseases Antibodies  >171 publications with VDR and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >171 publications with VDR and Prostatic Neoplasms
 Hypercalcemia Antibodies  >131 publications with VDR and Hypercalcemia
 Genetic Diseases, Inborn Antibodies  >107 publications with VDR and Genetic Diseases, Inborn
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1265 publications with VDR and Bone
 Blood Antibodies  >959 publications with VDR and Blood
 Kidney Antibodies  >543 publications with VDR and Kidney
 Parathyroid Antibodies  >404 publications with VDR and Parathyroid
 Skin Antibodies  >308 publications with VDR and Skin
 Intestine Antibodies  >306 publications with VDR and Intestine
 Prostate Antibodies  >259 publications with VDR and Prostate
 Connective Tissue Antibodies  >203 publications with VDR and Connective Tissue
 Muscle Antibodies  >172 publications with VDR and Muscle
 Brain Antibodies  >110 publications with VDR and Brain
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