BC007452
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,385 Da
NCBI Official Full Name
Homo sapiens WW domain binding protein 2, mRNA
NCBI Official Synonym Full Names
WW domain binding protein 2
NCBI Protein Information
WW domain-binding protein 2
UniProt Protein Name
WW domain-binding protein 2
UniProt Synonym Gene Names
NCBI Summary for WBP2
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]
UniProt Comments for WBP2
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR ().
Research Articles on WBP2
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Diseases associated with anti-WBP2 antibody
Organs/Tissues associated with anti-WBP2 antibody
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