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anti-WNT5A antibody :: Mouse anti-Human WNT5A Antibody

Scan QR to view Datasheet Catalog #    MBS850867
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WNT5A, Antibody

★Popular Item★
 Also Known As   

WNT5A Antibody

 Product Synonym Names    hWNT5A
 Product Gene Name   

anti-WNT5A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164975
 3D Structure    ModBase 3D Structure for P41221
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 Isotype    IgG1
 Clone Number    6F2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of WNT5A expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-WNT5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WNT5A antibody

   WNT5A: wingless-type MMTV integration site family, member 5A. Entrez Protein: NP_003383. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.
 Product Categories/Family for anti-WNT5A antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-WNT5A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-WNT5A antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-WNT5A antibody    Figure 1: Western blot analysis using WNT5A mouse mAb against HEK293 (1) and WNT5A-hIgGFc transfected HEK293 cell lysate (2). Figure 1: Western blot Figure 1:
anti-WNT5A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-WNT5A antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), thyroid cancer (B), lymph node (C) and brain (D) showing cytoplasmic and extracellular matrix localization using WNT5A mouse mAb with DAB staining.
anti-WNT5A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-WNT5A antibody    Figure 3: Confocal immunofluorescence analysis of PC-12 cells using WNT5A mouse mAb (green), showing cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
anti-WNT5A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for WNT5A. It may not necessarily be applicable to this product.
 NCBI GI #    371502087
 NCBI GeneID    7474
 NCBI Accession #    NP_001243034.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256105.1 [Other Products]
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 UniProt Primary Accession #    P41221 [Other Products]
 UniProt Secondary Accession #    Q6P278; A8K4A4 [Other Products]
 UniProt Related Accession #    P41221 [Other Products]
 Molecular Weight    42.3kDa
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 NCBI Official Full Name    protein Wnt-5a isoform 2
 NCBI Official Synonym Full Names    Wnt family member 5A
 NCBI Official Symbol    WNT5A [Similar Products]
 NCBI Official Synonym Symbols   
hWNT5A
[Similar Products]
 NCBI Protein Information    protein Wnt-5a
 UniProt Protein Name    Protein Wnt-5a
 Protein Family    Protein
 UniProt Gene Name    WNT5A [Similar Products]
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 NCBI Summary for WNT5A    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for WNT5A    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes ().
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 Research Articles on WNT5A    1. These findings suggest that WNT-5A modulates fundamental mechanisms that affect airway smooth muscle contraction and thus may be of relevance for airway hyperresponsiveness in asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WNT5A antibodyPathways associated with anti-WNT5A antibody
 Reference Product  PubMed Publications
 FZD2 antibody  >37 publications with WNT5A and FZD2
 LRP5 antibody  >31 publications with WNT5A and LRP5
 FZD5 antibody  >24 publications with WNT5A and FZD5
 FZD1 antibody  >21 publications with WNT5A and FZD1
 DVL2 antibody  >20 publications with WNT5A and DVL2
 FZD7 antibody  >16 publications with WNT5A and FZD7
 FZD4 antibody  >12 publications with WNT5A and FZD4
 DVL3 antibody  >10 publications with WNT5A and DVL3
 FZD8 antibody  >5 publications with WNT5A and FZD8
 DVL1 antibody  >5 publications with WNT5A and DVL1
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-WNT5A antibodyOrgans/Tissues associated with anti-WNT5A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >243 publications with WNT5A and Neoplasms
 Breast Neoplasms Antibodies  >44 publications with WNT5A and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >43 publications with WNT5A and Neoplasm Metastasis
 Inflammation Antibodies  >37 publications with WNT5A and Inflammation
 Adenocarcinoma Antibodies  >35 publications with WNT5A and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >33 publications with WNT5A and Neoplasms, Experimental
 Female Urogenital Diseases Antibodies  >28 publications with WNT5A and Female Urogenital Diseases
 Skin Neoplasms Antibodies  >26 publications with WNT5A and Skin Neoplasms
 Nervous System Diseases Antibodies  >25 publications with WNT5A and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >20 publications with WNT5A and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >136 publications with WNT5A and Bone
 Embryonic Tissue Antibodies  >127 publications with WNT5A and Embryonic Tissue
 Brain Antibodies  >84 publications with WNT5A and Brain
 Skin Antibodies  >62 publications with WNT5A and Skin
 Lung Antibodies  >47 publications with WNT5A and Lung
 Muscle Antibodies  >47 publications with WNT5A and Muscle
 Bone Marrow Antibodies  >42 publications with WNT5A and Bone Marrow
 Nerve Antibodies  >40 publications with WNT5A and Nerve
 Connective Tissue Antibodies  >34 publications with WNT5A and Connective Tissue
 Uterus Antibodies  >31 publications with WNT5A and Uterus
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