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anti-XRCC4 antibody :: anti-Human XRCC4 Antibody

Scan QR to view Datasheet Catalog #    MBS851102
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XRCC4, Antibody

 Also Known As   

XRCC4 Antibody

 Product Synonym Names    DNA-repair protein XRCC4; X-ray repair cross-complementing protein 4
 Product Gene Name   

anti-XRCC4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    194363
 3D Structure    ModBase 3D Structure for Q13426
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 Species Reactivity    Human
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 Specificity    XRCC4 antibody detects endogenous levels of total XRCC4 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from Internal of human XRCC4.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-XRCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-XRCC4 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-XRCC4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-XRCC4 antibody    WB: 1:500~1:1000
ELISA: 1:20000
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 Western Blot (WB) of anti-XRCC4 antibody    Western blot analysis of extracts from COLO205 cells, using XRCC4 antibody.
anti-XRCC4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XRCC4. It may not necessarily be applicable to this product.
 NCBI GI #    966751406
 NCBI GeneID    7518
 NCBI Accession #    NP_001304941.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001318012.1 [Other Products]
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 UniProt Primary Accession #    Q13426 [Other Products]
 UniProt Secondary Accession #    Q9BS72; Q9UP94; A8K3X4 [Other Products]
 UniProt Related Accession #    Q13426 [Other Products]
 Molecular Weight    35,372 Da
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 NCBI Official Full Name    DNA repair protein XRCC4 isoform 2
 NCBI Official Synonym Full Names    X-ray repair cross complementing 4
 NCBI Official Symbol    XRCC4 [Similar Products]
 NCBI Official Synonym Symbols   
SSMED
[Similar Products]
 NCBI Protein Information    DNA repair protein XRCC4
 UniProt Protein Name    DNA repair protein XRCC4
 UniProt Synonym Protein Names   
X-ray repair cross-complementing protein 4
 Protein Family    Xrcc4-like factor
 UniProt Gene Name    XRCC4 [Similar Products]
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 NCBI Summary for XRCC4    The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for XRCC4    Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
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Product References and Citations for anti-XRCC4 antibody

   Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196. Jérôme Drouet, J. Biol. Chem., Feb 2005; 280: 7060-7069. Ulf Grawunder, J. Biol. Chem., Sep 1998; 273: 24708. Ray Leber, J. Biol. Chem., Jan 1998; 273: 1794.
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 Research Articles on XRCC4    1. Variant rs3734091 was found to be significantly associated with breast cancer while rs6869366 variant did not show any association. These SNPs may influence the susceptibility of individuals to breast cancer in this Indian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC4 antibodyPathways associated with anti-XRCC4 antibody
 Reference Product  PubMed Publications
 LIG4 antibody  >145 publications with XRCC4 and LIG4
 XRCC6 antibody  >107 publications with XRCC4 and XRCC6
 XRCC5 antibody  >76 publications with XRCC4 and XRCC5
 PRKDC antibody  >68 publications with XRCC4 and PRKDC
 NHEJ1 antibody  >53 publications with XRCC4 and NHEJ1
 MRE11A antibody  >14 publications with XRCC4 and MRE11A
 APLF antibody  >12 publications with XRCC4 and APLF
 PNKP antibody  >6 publications with XRCC4 and PNKP
 APTX antibody  >4 publications with XRCC4 and APTX
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
 Integration Of Provirus Pathway antibodies  Integration Of Provirus Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-XRCC4 antibodyOrgans/Tissues associated with anti-XRCC4 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >42 publications with XRCC4 and Chromosome Aberrations
 Nervous System Diseases Antibodies  >17 publications with XRCC4 and Nervous System Diseases
 Lung Neoplasms Antibodies  >12 publications with XRCC4 and Lung Neoplasms
 Chromosome Breakage Antibodies  >12 publications with XRCC4 and Chromosome Breakage
 Neoplasms, Experimental Antibodies  >9 publications with XRCC4 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >7 publications with XRCC4 and Adenocarcinoma
 Urinary Bladder Neoplasms Antibodies  >6 publications with XRCC4 and Urinary Bladder Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with XRCC4 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >5 publications with XRCC4 and Kidney Diseases
 Liver Neoplasms Antibodies  >4 publications with XRCC4 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >59 publications with XRCC4 and Blood
 Brain Antibodies  >16 publications with XRCC4 and Brain
 Prostate Antibodies  >8 publications with XRCC4 and Prostate
 Kidney Antibodies  >8 publications with XRCC4 and Kidney
 Liver Antibodies  >8 publications with XRCC4 and Liver
 Bone Marrow Antibodies  >8 publications with XRCC4 and Bone Marrow
 Skin Antibodies  >7 publications with XRCC4 and Skin
 Embryonic Tissue Antibodies  >5 publications with XRCC4 and Embryonic Tissue
 Vascular Antibodies  >4 publications with XRCC4 and Vascular
 Lymph Node Antibodies  >3 publications with XRCC4 and Lymph Node
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