NP_001139626.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,499 Da
NCBI Official Full Name
prostaglandin reductase 2
NCBI Official Synonym Full Names
prostaglandin reductase 2
NCBI Official Synonym Symbols
NCBI Protein Information
prostaglandin reductase 2; PRG-2; 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin-delta13-reductase; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1
UniProt Protein Name
Prostaglandin reductase 2
UniProt Synonym Protein Names
15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
PTGR2_HUMAN
NCBI Summary for ZADH1
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
UniProt Comments for ZADH1
PTGR2: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Belongs to the NADP-dependent oxidoreductase L4BD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.3.1.48; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cytoplasm
Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion binding
Biological Process: prostaglandin metabolic process
Research Articles on ZADH1
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Diseases associated with anti-ZADH1 antibody
Organs/Tissues associated with anti-ZADH1 antibody
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