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anti-CTNNB1 antibody :: beta-Catenin Antibody

Scan QR to view Datasheet Catalog #    MBS856671
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta-Catenin (CTNNB1), Antibody

 Also Known As   

beta-Catenin (Ab-37) Antibody

 Product Gene Name   

anti-CTNNB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114500
 3D Structure    ModBase 3D Structure for P35222
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    beta-Catenin (Ab-37) antibody detects endogenous levels of total beta-Catenin protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human beta-Catenin around the phosphorylation site of serine 37 (I-H-SP-G-A).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-CTNNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CTNNB1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CTNNB1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CTNNB1 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:200
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 Immunohistochemistry (IHC) of anti-CTNNB1 antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using beta-Catenin (Ab-37) antibody.
anti-CTNNB1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CTNNB1 antibody    Western blot analysis of extract from SW 626 cells, using beta-Catenin (Ab-37) antibody and beta-Catenin (phospho-Ser37) antibody.
anti-CTNNB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CTNNB1. It may not necessarily be applicable to this product.
 NCBI GI #    148233338
 NCBI GeneID    1499
 NCBI Accession #    NP_001091679.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098209.1 [Other Products]
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 UniProt Primary Accession #    P35222 [Other Products]
 UniProt Secondary Accession #    Q8NEW9; Q8NI94; Q9H391; A8K1L7 [Other Products]
 UniProt Related Accession #    P35222 [Other Products]
 Molecular Weight    85,497 Da [Similar Products]
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 NCBI Official Full Name    catenin beta-1 isoform 1
 NCBI Official Synonym Full Names    catenin beta 1
 NCBI Official Symbol    CTNNB1 [Similar Products]
 NCBI Official Synonym Symbols   
EVR7; CTNNB; MRD19; armadillo
[Similar Products]
 NCBI Protein Information    catenin beta-1
 UniProt Protein Name    Catenin beta-1
 UniProt Synonym Protein Names   
Beta-catenin
 Protein Family    Beta-catenin-like protein
 UniProt Gene Name    CTNNB1 [Similar Products]
 UniProt Synonym Gene Names    CTNNB [Similar Products]
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 NCBI Summary for CTNNB1    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
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 UniProt Comments for CTNNB1    Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle ().
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Product References and Citations for anti-CTNNB1 antibody

   Novak A, et al. (1998) Proc Natl Acad Sci U S A; 95(8): 4374-4379 Marin O, et al. (2003) Proc Natl Acad Sci U S A; 100(18): 10193-10200 Okamura H, et al. (2004) Mol Cell Biol; 24(10): 4184-4195 Xing Y, et al. (2003) Genes Dev; 17(22): 2753-2764 Barth AI, et al. (1999) Proc Natl Acad Sci U S A; 96(9): 4947-4952.
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 Research Articles on CTNNB1    1. Muclear pbeta-cateninS552 staining discriminates between patients with inflammation and those with a history of low grade dysplasia, suggesting that nuclear pbeta-cateninS552 staining may reflect local expansions of activated stem cells with neoplastic potential.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CTNNB1 antibodyPathways associated with anti-CTNNB1 antibody
 Reference Product  PubMed Publications
 APC antibody  >1618 publications with CTNNB1 and APC
 CCND1 antibody  >1196 publications with CTNNB1 and CCND1
 LEF1 antibody  >401 publications with CTNNB1 and LEF1
 DKK1 antibody  >379 publications with CTNNB1 and DKK1
 CTNNA1 antibody  >347 publications with CTNNB1 and CTNNA1
 TCF7L2 antibody  >333 publications with CTNNB1 and TCF7L2
 EGFR antibody  >271 publications with CTNNB1 and EGFR
 CASP3 antibody  >250 publications with CTNNB1 and CASP3
 AXIN2 antibody  >234 publications with CTNNB1 and AXIN2
 MET antibody  >169 publications with CTNNB1 and MET
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
Diseases associated with anti-CTNNB1 antibodyOrgans/Tissues associated with anti-CTNNB1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6906 publications with CTNNB1 and Neoplasms
 Intestinal Neoplasms Antibodies  >2109 publications with CTNNB1 and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >2044 publications with CTNNB1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1615 publications with CTNNB1 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >1168 publications with CTNNB1 and Colonic Neoplasms
 Adenoma Antibodies  >831 publications with CTNNB1 and Adenoma
 Liver Neoplasms Antibodies  >801 publications with CTNNB1 and Liver Neoplasms
 Liver Diseases Antibodies  >778 publications with CTNNB1 and Liver Diseases
 Breast Neoplasms Antibodies  >662 publications with CTNNB1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >576 publications with CTNNB1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1288 publications with CTNNB1 and Bone
 Liver Antibodies  >1203 publications with CTNNB1 and Liver
 Embryonic Tissue Antibodies  >1078 publications with CTNNB1 and Embryonic Tissue
 Brain Antibodies  >1047 publications with CTNNB1 and Brain
 Blood Antibodies  >962 publications with CTNNB1 and Blood
 Vascular Antibodies  >850 publications with CTNNB1 and Vascular
 Intestine Antibodies  >842 publications with CTNNB1 and Intestine
 Lung Antibodies  >774 publications with CTNNB1 and Lung
 Muscle Antibodies  >770 publications with CTNNB1 and Muscle
 Kidney Antibodies  >709 publications with CTNNB1 and Kidney
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