NP_001091679.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
catenin beta-1 isoform 1
NCBI Official Synonym Full Names
catenin beta 1
NCBI Protein Information
catenin beta-1
UniProt Protein Name
Catenin beta-1
UniProt Synonym Protein Names
Beta-catenin
UniProt Synonym Gene Names
NCBI Summary for CTNNB1
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
UniProt Comments for CTNNB1
CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: adherens junction; basolateral plasma membrane; beta-catenin destruction complex; catenin complex; cell cortex; cell junction; cell-cell adherens junction; centrosome; cytoplasm; cytosol; focal adhesion; intercellular junction; lateral plasma membrane; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; transcription factor complex
Molecular Function: alpha-catenin binding; cadherin binding; enzyme binding; estrogen receptor binding; kinase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein phosphatase binding; SMAD binding; transcription coactivator activity; transcription factor binding
Biological Process: cell adhesion; cell-cell adhesion; epithelial to mesenchymal transition; hair cell differentiation; negative regulation of cell proliferation; negative regulation of mitotic cell cycle, embryonic; negative regulation of protein sumoylation; negative regulation of transcription, DNA-dependent; patterning of blood vessels; positive regulation of apoptosis; positive regulation of histone H3-K4 methylation; positive regulation of interferon type I production; positive regulation of muscle cell differentiation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of angiogenesis; regulation of centriole-centriole cohesion; regulation of fibroblast proliferation; regulation of neurogenesis; regulation of smooth muscle cell proliferation; response to drug; response to estradiol stimulus; stem cell maintenance; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Colorectal Cancer; Hepatocellular Carcinoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Pilomatrixoma
Research Articles on CTNNB1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CTNNB1 antibody
Pathways associated with anti-CTNNB1 antibody
Diseases associated with anti-CTNNB1 antibody
Organs/Tissues associated with anti-CTNNB1 antibody
|