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anti-MYC antibody :: Human anti-Human c-myc epitope tag Antibody

Scan QR to view Datasheet Catalog #    MBS488003 anti-MYC antibody
Unit / Price
0.2 mg  /  $375 +1 FREE 8GB USB
1 mg  /  $1,410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-myc epitope tag, Antibody

 Also Known As   

Anti-c-myc epitope tag [9E10]

 Product Synonym Names    Proto-oncogene c-Myc; Transcription factor p64; Class E basic helix-loop-helix protein 39; BHLHE39; cmyc
 Product Gene Name   

anti-MYC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L00058,  3D Structure    ModBase 3D Structure for P01106
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 Isotype    IgG1, kappa
 Clone Number    9E10
 Host    Human
 Species Reactivity    Human
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 Specificity    Epitope sequence, EQKLISEEDL, located in aa 410-419 of human c-myc protein.
 Purity/Purification    Protein A Affinity Purified
 Form/Format    PBS with preservative (0.02% Proclin 300)
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 Buffer Composition    PBS only.
 Immunogen    A synthetic peptide corresponding to aa 408-439 from C-terminus of human c-myc.
 Chimeric Use Statement    This is a chimeric human antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
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 Preparation and Storage    Store at 4 degree C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MYC antibody

   Recombinant monoclonal antibody to c-myc epitope tag. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9E10. This is a chimeric human antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
 Product Categories/Family for anti-MYC antibody    Epitope tag
 Applications Tested/Suitable for anti-MYC antibody   

Immunohistochemistry (IHC) Formalin/Paraffin, Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
 NCBI GI #    127619
 NCBI GeneID    4609
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 UniProt Primary Accession #    P01106 [Other Products]
 UniProt Secondary Accession #    P01107; Q14026; A8WFE7 [Other Products]
 UniProt Related Accession #    P01106 [Other Products]
 Molecular Weight    50,565 Da [Similar Products]
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 NCBI Official Full Name    Myc proto-oncogene protein
 NCBI Official Synonym Full Names    v-myc avian myelocytomatosis viral oncogene homolog
 NCBI Official Symbol    MYC [Similar Products]
 NCBI Official Synonym Symbols   
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
 NCBI Protein Information    myc proto-oncogene protein
 UniProt Protein Name    Myc proto-oncogene protein
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
 Protein Family    Myc protein
 UniProt Gene Name    MYC [Similar Products]
 UniProt Synonym Gene Names    BHLHE39; bHLHe39 [Similar Products]
 UniProt Entry Name    MYC_HUMAN
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 NCBI Summary for MYC    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYC    Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; regulation of telomere maintenance; response to DNA damage stimulus; response to drug; response to gamma radiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma
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Product References and Citations for anti-MYC antibody

   Evan GI, Lewis GK, Ramsay G, Bishop JM. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol. 1985 Dec; 5(12):3610-6. PMID:3915782
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 Research Articles on MYC    1. These results indicate that miR-25 has anti-apoptosis roles in AGS cells, possibly via inhibiting FBXW7 and thus promoting oncogenes, such as CCNE1 and MYC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYC antibodyPathways associated with anti-MYC antibody
 Reference Product  PubMed Publications
 MAX antibody  >1115 publications with MYC and MAX
 CDKN2A antibody  >436 publications with MYC and CDKN2A
 GSK3B antibody  >144 publications with MYC and GSK3B
 FBXW7 antibody  >130 publications with MYC and FBXW7
 SKP2 antibody  >109 publications with MYC and SKP2
 ZBTB17 antibody  >55 publications with MYC and ZBTB17
 EP300 antibody  >26 publications with MYC and EP300
 KAT5 antibody  >17 publications with MYC and KAT5
 PFDN5 antibody  >16 publications with MYC and PFDN5
 SUPT3H antibody  >4 publications with MYC and SUPT3H
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Association Between Physico-Chemical Features And Toxicity Associated Pathways antibodies  Association Between Physico-Chemical Features And Toxicity Associated Pathways Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway antibodies  Binding Of TCF/LEF:CTNNB1 To Target Gene Promoters Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
Diseases associated with anti-MYC antibodyOrgans/Tissues associated with anti-MYC antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4383 publications with MYC and Carcinoma
 Neuroectodermal Tumors Antibodies  >2865 publications with MYC and Neuroectodermal Tumors
 Cell Transformation, Neoplastic Antibodies  >2801 publications with MYC and Cell Transformation, Neoplastic
 Neuroblastoma Antibodies  >2064 publications with MYC and Neuroblastoma
 Adenocarcinoma Antibodies  >1937 publications with MYC and Adenocarcinoma
 Breast Neoplasms Antibodies  >1646 publications with MYC and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1533 publications with MYC and Neoplasms, Experimental
 Disease Progression Antibodies  >1337 publications with MYC and Disease Progression
 Liver Neoplasms Antibodies  >1246 publications with MYC and Liver Neoplasms
 Lung Neoplasms Antibodies  >1057 publications with MYC and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4036 publications with MYC and Blood
 Liver Antibodies  >2232 publications with MYC and Liver
 Lung Antibodies  >1662 publications with MYC and Lung
 Bone Antibodies  >1594 publications with MYC and Bone
 Brain Antibodies  >1435 publications with MYC and Brain
 Muscle Antibodies  >1251 publications with MYC and Muscle
 Bone Marrow Antibodies  >1104 publications with MYC and Bone Marrow
 Vascular Antibodies  >1052 publications with MYC and Vascular
 Kidney Antibodies  >921 publications with MYC and Kidney
 Prostate Antibodies  >888 publications with MYC and Prostate
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