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anti-eIF4E antibody :: eIF4E Antibody

Scan QR to view Datasheet Catalog #    MBS857179
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

eIF4E, Antibody

★Popular Item★
 Also Known As   

eIF4E (Phospho-Ser209) Antibody

 Product Gene Name   

anti-eIF4E antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133440
 3D Structure    ModBase 3D Structure for P06730
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    elF4E (phospho-Ser209) antibody detects endogenous levels of elF4E only when phosphorylated at serine 209.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human elF4E around the phosphorylation site of serine 209 (S-G-SP-T-T).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-eIF4E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-eIF4E antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-eIF4E antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-eIF4E antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
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 Immunohistochemistry (IHC) of anti-eIF4E antibody    P-Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using elF4E (phospho-Ser209) antibody.
anti-eIF4E antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-eIF4E antibody    Western blot analysis of extract from NIH/3T3 cells untreated or treated with 10% serum (15min), using elF4E (Ab-209) antibody and elF4E (phospho-Ser209) antibody.
anti-eIF4E antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for eIF4E. It may not necessarily be applicable to this product.
 NCBI GI #    194578907
 NCBI GeneID    1977
 NCBI Accession #    NP_001124150.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130678.2 [Other Products]
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 UniProt Primary Accession #    P06730 [Other Products]
 UniProt Secondary Accession #    Q96E95; B7Z6V1; D6RCQ6 [Other Products]
 UniProt Related Accession #    P06730 [Other Products]
 Molecular Weight    27,260 Da
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 NCBI Official Full Name    eukaryotic translation initiation factor 4E isoform 3
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E
 NCBI Official Symbol    EIF4E [Similar Products]
 NCBI Official Synonym Symbols   
CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E
 UniProt Protein Name    Eukaryotic translation initiation factor 4E
 UniProt Synonym Protein Names   
eIF-4F 25 kDa subunit; mRNA cap-binding protein
 Protein Family    Eukaryotic translation initiation factor
 UniProt Gene Name    EIF4E [Similar Products]
 UniProt Synonym Gene Names    EIF4EL1; EIF4F; eIF-4E; eIF4E [Similar Products]
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 NCBI Summary for eIF4E    The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for eIF4E    Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
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Product References and Citations for anti-eIF4E antibody

   Li BD, et al. (1998) Ann Surg; 227(5): 756-763 Altmann M, et al. (1989) Nucleic Acids Res; 17(18): 7520 De Gregorio E, et al. (2001) RNA; 7(1): 106-113 Gu W, et al. (2004) Nucleic Acids Res; 32(15): 4448-4461.
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 Research Articles on eIF4E    1. The present study indicated that miR-15a downregulation was associated with cell proliferation and invasion by directly targeting eIF4E during RCC progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-eIF4E antibodyPathways associated with anti-eIF4E antibody
 Reference Product  PubMed Publications
 EIF4EBP1 antibody  >460 publications with eIF4E and EIF4EBP1
 MKNK1 antibody  >72 publications with eIF4E and MKNK1
 EIF4B antibody  >46 publications with eIF4E and EIF4B
 EIF4EBP2 antibody  >43 publications with eIF4E and EIF4EBP2
 EIF4G1 antibody  >43 publications with eIF4E and EIF4G1
 MKNK2 antibody  >25 publications with eIF4E and MKNK2
 PML antibody  >19 publications with eIF4E and PML
 EIF4G2 antibody  >17 publications with eIF4E and EIF4G2
 EIF4ENIF1 antibody  >13 publications with eIF4E and EIF4ENIF1
 EIF4EBP3 antibody  >9 publications with eIF4E and EIF4EBP3
 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
Diseases associated with anti-eIF4E antibodyOrgans/Tissues associated with anti-eIF4E antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >543 publications with eIF4E and Neoplasms
 Carcinoma Antibodies  >185 publications with eIF4E and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >101 publications with eIF4E and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >72 publications with eIF4E and Adenocarcinoma
 Nervous System Diseases Antibodies  >64 publications with eIF4E and Nervous System Diseases
 Hypertrophy Antibodies  >52 publications with eIF4E and Hypertrophy
 Necrosis Antibodies  >48 publications with eIF4E and Necrosis
 Neoplasms, Experimental Antibodies  >46 publications with eIF4E and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >45 publications with eIF4E and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >42 publications with eIF4E and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >310 publications with eIF4E and Muscle
 Blood Antibodies  >250 publications with eIF4E and Blood
 Liver Antibodies  >126 publications with eIF4E and Liver
 Brain Antibodies  >116 publications with eIF4E and Brain
 Vascular Antibodies  >103 publications with eIF4E and Vascular
 Heart Antibodies  >86 publications with eIF4E and Heart
 Lung Antibodies  >75 publications with eIF4E and Lung
 Kidney Antibodies  >69 publications with eIF4E and Kidney
 Nerve Antibodies  >41 publications with eIF4E and Nerve
 Pancreas Antibodies  >38 publications with eIF4E and Pancreas
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