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anti-eNOS antibody :: Rabbit eNOS Antibody

Scan QR to view Datasheet Catalog #    MBS852269
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

eNOS, Antibody

★Popular Item★
 Also Known As   

eNOS (Phospho-Ser615) Antibody

 Product Synonym Names    Constitutive NOS; EC 1.14.13.39; EC-NOS; ECNOS; Endothelial NOS; NOS; type III; NOS3; NOSIII; Nitric-oxide synthase; endothelial; cNOS
 Product Gene Name   

anti-eNOS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163729
 3D Structure    ModBase 3D Structure for P29474
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    eNOS (Phospho-Ser615) antibody detects endogenous levels of eNOS only when phosphorylated at serine 615.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human eNOS around the phosphorylation site of serine 615 (F-N-SP-I-S).
 All Sites    Human: Ser615; Mouse: Ser614; Rat: Ser614
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-eNOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-eNOS antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-eNOS antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-eNOS antibody    WB: 1:500~1:1000, ELISA: 1:40000
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 Testing Data of anti-eNOS antibody    Western blot analysis of extracts from K562 cells, treated with EGF (40nM, 30mins), using eNOS (Phospho-Ser615) antibody.
anti-eNOS antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for eNOS. It may not necessarily be applicable to this product.
 NCBI GI #    40254422
 NCBI GeneID    4846
 NCBI Accession #    NP_000594.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000603.4 [Other Products]
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 UniProt Primary Accession #    P29474 [Other Products]
 UniProt Secondary Accession #    Q13662; Q14251; Q14434; Q548C1; Q6GSL5; Q9UDC6; A0S0A7; A0S0A8; A8KA63; B2RCQ1; E9PFR2 [Other Products]
 UniProt Related Accession #    P29474 [Other Products]
 Molecular Weight    67,876 Da
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 NCBI Official Full Name    nitric oxide synthase, endothelial isoform 1
 NCBI Official Synonym Full Names    nitric oxide synthase 3 (endothelial cell)
 NCBI Official Symbol    NOS3 [Similar Products]
 NCBI Official Synonym Symbols   
eNOS; ECNOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, endothelial; cNOS; EC-NOS; NOSIII; NOS type III; endothelial NOS; constitutive NOS; nitric oxide synthase 3 transcript variant eNOS-delta20; nitric oxide synthase 3 transcript variant eNOS-delta21; nitric oxide synthase 3 transcript variant eNOS-delta20-21
 UniProt Protein Name    Nitric oxide synthase, endothelial
 UniProt Synonym Protein Names   
Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII
 UniProt Gene Name    NOS3 [Similar Products]
 UniProt Synonym Gene Names    cNOS; eNOS; NOSIII [Similar Products]
 UniProt Entry Name    NOS3_HUMAN
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 NCBI Summary for eNOS    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
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 UniProt Comments for eNOS    eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Protein type: Oxidoreductase; EC 1.14.13.39; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: Golgi membrane; cytoskeleton; cytoplasm; plasma membrane; caveola; nucleus; cytosol

Molecular Function: actin monomer binding; calmodulin binding; protein binding; FAD binding; FMN binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; iron ion binding; heme binding; NADP binding; cadmium ion binding

Biological Process: regulation of systemic arterial blood pressure by endothelin; negative regulation of potassium ion transport; negative regulation of muscle hyperplasia; positive regulation of vasodilation; nitric oxide metabolic process; negative regulation of cell proliferation; regulation of the force of heart contraction by chemical signal; regulation of blood pressure; negative regulation of hydrolase activity; lipopolysaccharide-mediated signaling pathway; negative regulation of blood pressure; angiogenesis; regulation of blood vessel size; nitric oxide biosynthetic process; mitochondrion organization and biogenesis; interaction with host; negative regulation of calcium ion transport; in utero embryonic development; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; ovulation from ovarian follicle; positive regulation of angiogenesis; response to heat; endothelial cell migration; arginine catabolic process; blood vessel remodeling; regulation of nitric-oxide synthase activity; vascular endothelial growth factor receptor signaling pathway; blood coagulation; nitric oxide mediated signal transduction; lung development; smooth muscle hyperplasia

Disease: Preeclampsia/eclampsia 1; Alzheimer Disease; Hypertension, Essential; Stroke, Ischemic
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Product References and Citations for anti-eNOS antibody

   Janssens S.P., J. Biol. Chem. 267:14519-14522(1992).
Janssens S.P., J. Biol. Chem. 267:22694-22694(1992).
Marsden P.A., FEBS Lett. 307:287-293(1992).
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 Research Articles on eNOS    1. eNOS gene polymorphism is associated with graft function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-eNOS antibodyDiseases associated with anti-eNOS antibody
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2127 publications with eNOS and Cardiovascular Diseases
 Hypertension Antibodies  >1051 publications with eNOS and Hypertension
 Myocardial Ischemia Antibodies  >573 publications with eNOS and Myocardial Ischemia
 Ischemia Antibodies  >556 publications with eNOS and Ischemia
 Atherosclerosis Antibodies  >460 publications with eNOS and Atherosclerosis
 Reperfusion Injury Antibodies  >285 publications with eNOS and Reperfusion Injury
 Myocardial Infarction Antibodies  >256 publications with eNOS and Myocardial Infarction
 Coronary Artery Disease Antibodies  >253 publications with eNOS and Coronary Artery Disease
 Cerebral Infarction Antibodies  >202 publications with eNOS and Cerebral Infarction
 Diabetes Mellitus, Experimental Antibodies  >199 publications with eNOS and Diabetes Mellitus, Experimental
Organs/Tissues associated with anti-eNOS antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3585 publications with eNOS and Vascular
 Blood Antibodies  >2726 publications with eNOS and Blood
 Heart Antibodies  >1257 publications with eNOS and Heart
 Kidney Antibodies  >542 publications with eNOS and Kidney
 Brain Antibodies  >442 publications with eNOS and Brain
 Lung Antibodies  >383 publications with eNOS and Lung
 Liver Antibodies  >270 publications with eNOS and Liver
 Embryonic Tissue Antibodies  >211 publications with eNOS and Embryonic Tissue
 Bone Antibodies  >150 publications with eNOS and Bone
 Skin Antibodies  >95 publications with eNOS and Skin
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