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anti-iNOS antibody :: Rabbit iNOS Antibody

Scan QR to view Datasheet Catalog #    MBS853218
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

iNOS, Antibody

 Also Known As   

iNOS (Phospho-Tyr151) Antibody

 Product Synonym Names    EC 1.14.13.39; HEP-NOS; hepatocyte NOS; inducible NOS; nitric oxide synthase; inducible; NOS type II; NOS2; NOS2A
 Product Gene Name   

anti-iNOS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 611162
 3D Structure    ModBase 3D Structure for P35228
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Inos (Phospho-Tyr151) antibody detects endogenous levels of Inos only when phosphorylated at tyrosine 151.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%); Rat (Identities = 92%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Inos around the phosphorylation site of tyrosine 151 (Q-Y-YP-G-S).
 All Sites    Human: Tyr151; Mouse: Tyr145; Rat: Tyr151
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-iNOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-iNOS antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-iNOS antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-iNOS antibody    IHC: 1:50~1:100, ELISA: 1:10000
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 Testing Data of anti-iNOS antibody    P-peptide - +
anti-iNOS antibody Testing Data image
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 Testing Data #2 of anti-iNOS antibody    Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Inos (Phospho-Tyr151) antibody.
Inos (Phospho-Tyr151) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-iNOS antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for iNOS. It may not necessarily be applicable to this product.
 NCBI GI #    24041029
 NCBI GeneID    4843
 NCBI Accession #    NP_000616.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000625.4 [Other Products]
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 UniProt Primary Accession #    P35228 [Other Products]
 UniProt Secondary Accession #    O60757; O94994; Q16263; Q16692; Q4TTS5; Q9UD42; A1L3U5; B7ZLY2 [Other Products]
 UniProt Related Accession #    P35228 [Other Products]
 Molecular Weight    126,749 Da
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 NCBI Official Full Name    nitric oxide synthase, inducible
 NCBI Official Synonym Full Names    nitric oxide synthase 2, inducible
 NCBI Official Symbol    NOS2 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; INOS; NOS2A; HEP-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, inducible; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes)
 UniProt Protein Name    Nitric oxide synthase, inducible
 UniProt Synonym Protein Names   
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
 Protein Family    Inositol 3-kinase
 UniProt Gene Name    NOS2 [Similar Products]
 UniProt Synonym Gene Names    NOS2A; HEP-NOS; Inducible NOS; iNOS [Similar Products]
 UniProt Entry Name    NOS2_HUMAN
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 NCBI Summary for iNOS    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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 UniProt Comments for iNOS    iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Homodimer. Binds SLC9A3R1. By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Belongs to the NOS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Amino Acid Metabolism - arginine and proline; EC 1.14.13.39

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cortical cytoskeleton; perinuclear region of cytoplasm; cytoplasm; peroxisome; intracellular; cytosol; nucleus

Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; FAD binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity; FMN binding; iron ion binding; heme binding; NADP binding; receptor binding

Biological Process: circadian rhythm; interaction with host; superoxide metabolic process; positive regulation of guanylate cyclase activity; positive regulation of killing of cells of another organism; positive regulation of vasodilation; defense response to Gram-negative bacterium; regulation of cell proliferation; regulation of cellular respiration; positive regulation of leukocyte mediated cytotoxicity; response to bacterium; innate immune response in mucosa; defense response to bacterium; peptidyl-cysteine S-nitrosylation; response to hypoxia; arginine catabolic process; negative regulation of blood pressure; nitric oxide biosynthetic process; inflammatory response; negative regulation of protein catabolic process; blood coagulation; regulation of insulin secretion; nitric oxide mediated signal transduction

Disease: Hypertension, Essential; Malaria, Susceptibility To
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Product References and Citations for anti-iNOS antibody

   Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).
Sherman P.A., Biochemistry 32:11600-11605(1993).
Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).
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 Research Articles on iNOS    1. Macrophage MMP12 regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-iNOS antibodyDiseases associated with anti-iNOS antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2494 publications with iNOS and Inflammation
 Necrosis Antibodies  >2038 publications with iNOS and Necrosis
 Sepsis Antibodies  >573 publications with iNOS and Sepsis
 Intestinal Diseases Antibodies  >415 publications with iNOS and Intestinal Diseases
 Liver Diseases Antibodies  >380 publications with iNOS and Liver Diseases
 Reperfusion Injury Antibodies  >379 publications with iNOS and Reperfusion Injury
 Hypertension Antibodies  >299 publications with iNOS and Hypertension
 Endotoxemia Antibodies  >260 publications with iNOS and Endotoxemia
 Shock, Septic Antibodies  >250 publications with iNOS and Shock, Septic
 Kidney Diseases Antibodies  >225 publications with iNOS and Kidney Diseases
Organs/Tissues associated with anti-iNOS antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2698 publications with iNOS and Blood
 Brain Antibodies  >1123 publications with iNOS and Brain
 Lung Antibodies  >863 publications with iNOS and Lung
 Intestine Antibodies  >503 publications with iNOS and Intestine
 Pancreas Antibodies  >224 publications with iNOS and Pancreas
 Stomach Antibodies  >217 publications with iNOS and Stomach
 Connective Tissue Antibodies  >100 publications with iNOS and Connective Tissue
 Embryonic Tissue Antibodies  >90 publications with iNOS and Embryonic Tissue
 Mixed Antibodies  >73 publications with iNOS and Mixed
 Ovary Antibodies  >48 publications with iNOS and Ovary
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