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anti-iNOS antibody :: iNOS Antibody

Scan QR to view Datasheet Catalog #    MBS853218
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

iNOS, Antibody

 Also Known As   

iNOS (Phospho-Tyr151) Antibody

 Product Synonym Names    EC 1.14.13.39; HEP-NOS; hepatocyte NOS; inducible NOS; nitric oxide synthase; inducible; NOS type II; NOS2; NOS2A
 Product Gene Name   

anti-iNOS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163730
 3D Structure    ModBase 3D Structure for P35228
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Inos (Phospho-Tyr151) antibody detects endogenous levels of Inos only when phosphorylated at tyrosine 151.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Inos around the phosphorylation site of tyrosine 151 (Q-Y-YP-G-S).
 All Sites    Human: Tyr151
Mouse: Tyr145
Rat: Tyr151
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-iNOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-iNOS antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-iNOS antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-iNOS antibody    IHC: 1:50-1:100
ELISA: 1:10000
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 Testing Data of anti-iNOS antibody    P-peptide-+
anti-iNOS antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-iNOS antibody    Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Inos (Phospho-Tyr151) antibody. Inos (Phospho-Tyr151) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-iNOS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for iNOS. It may not necessarily be applicable to this product.
 NCBI GI #    24041029
 NCBI GeneID    4843
 NCBI Accession #    NP_000616.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000625.4 [Other Products]
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 UniProt Primary Accession #    P35228 [Other Products]
 UniProt Secondary Accession #    O60757; O94994; Q16263; Q16692; Q4TTS5; Q9UD42; A1L3U5; B7ZLY2 [Other Products]
 UniProt Related Accession #    P35228 [Other Products]
 Molecular Weight    126,749 Da
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 NCBI Official Full Name    nitric oxide synthase, inducible
 NCBI Official Synonym Full Names    nitric oxide synthase 2
 NCBI Official Symbol    NOS2 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; INOS; NOS2A; HEP-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, inducible
 UniProt Protein Name    Nitric oxide synthase, inducible
 UniProt Synonym Protein Names   
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
 Protein Family    Inositol 3-kinase
 UniProt Gene Name    NOS2 [Similar Products]
 UniProt Synonym Gene Names    NOS2A; HEP-NOS; Inducible NOS; iNOS [Similar Products]
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 NCBI Summary for iNOS    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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 UniProt Comments for iNOS    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
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Product References and Citations for anti-iNOS antibody

   Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993). Sherman P.A., Biochemistry 32:11600-11605(1993). Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).
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 Research Articles on iNOS    1. Collectively, our results demonstrated sanggenon C induced apoptosis of colon cancer cells by increased reactive oxygen species generation and decreased nitric oxide production, which is associated with inhibition of inducible nitric oxide synthase expression(iNOS) and activation of mitochondrial apoptosis pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-iNOS antibodyPathways associated with anti-iNOS antibody
 Reference Product  PubMed Publications
 SRC antibody  >34 publications with iNOS and SRC
 RAC1 antibody  >12 publications with iNOS and RAC1
 CAV1 antibody  >4 publications with iNOS and CAV1
 RAC2 antibody  >2 publications with iNOS and RAC2
 SLC9A3R1 antibody  >1 publications with iNOS and SLC9A3R1
 ACTN4 antibody  >1 publications with iNOS and ACTN4
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-iNOS antibodyOrgans/Tissues associated with anti-iNOS antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2190 publications with iNOS and Inflammation
 Necrosis Antibodies  >1844 publications with iNOS and Necrosis
 Sepsis Antibodies  >542 publications with iNOS and Sepsis
 Intestinal Diseases Antibodies  >370 publications with iNOS and Intestinal Diseases
 Liver Diseases Antibodies  >346 publications with iNOS and Liver Diseases
 Reperfusion Injury Antibodies  >346 publications with iNOS and Reperfusion Injury
 Hypertension Antibodies  >280 publications with iNOS and Hypertension
 Endotoxemia Antibodies  >248 publications with iNOS and Endotoxemia
 Shock, Septic Antibodies  >235 publications with iNOS and Shock, Septic
 Kidney Diseases Antibodies  >211 publications with iNOS and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2501 publications with iNOS and Blood
 Brain Antibodies  >1050 publications with iNOS and Brain
 Lung Antibodies  >810 publications with iNOS and Lung
 Intestine Antibodies  >451 publications with iNOS and Intestine
 Pancreas Antibodies  >211 publications with iNOS and Pancreas
 Stomach Antibodies  >208 publications with iNOS and Stomach
 Embryonic Tissue Antibodies  >88 publications with iNOS and Embryonic Tissue
 Connective Tissue Antibodies  >87 publications with iNOS and Connective Tissue
 Mixed Antibodies  >71 publications with iNOS and Mixed
 Ovary Antibodies  >45 publications with iNOS and Ovary
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