NP_004055.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,073 Da
NCBI Official Full Name
cyclin-dependent kinase inhibitor 1B
NCBI Official Synonym Full Names
cyclin dependent kinase inhibitor 1B
NCBI Official Synonym Symbols
KIP1; MEN4; CDKN4; MEN1B; P27KIP1 [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1B
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1B
UniProt Synonym Protein Names
Cyclin-dependent kinase inhibitor p27; p27Kip1
UniProt Synonym Gene Names
NCBI Summary for p27 Kip1
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
UniProt Comments for p27 Kip1
p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Protein type: Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12p13.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: caspase activator activity; cyclin-dependent protein kinase inhibitor activity; protein binding; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process: autophagic cell death; caspase activation; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of protein catabolic process; regulation of cyclin-dependent protein kinase activity
Disease: Multiple Endocrine Neoplasia, Type Iv
Research Articles on p27 Kip1
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Products associated with anti-p27 Kip1 antibody
Pathways associated with anti-p27 Kip1 antibody
Diseases associated with anti-p27 Kip1 antibody
Organs/Tissues associated with anti-p27 Kip1 antibody
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