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anti-P300/CBP antibody :: P300/CBP Antibody

Scan QR to view Datasheet Catalog #    MBS851705
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P300/CBP, Antibody

 Also Known As   

P300/CBP Antibody

 Product Synonym Names    CREB-binding protein; CREBBP E1A-associated protein p300; EP300; P300 transcription coactivator homolog
 Product Gene Name   

anti-P300/CBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602700
 3D Structure    ModBase 3D Structure for Q09472
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    P300/CBP antibody detects endogenous levels of total P300/CBP protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from human P300/CBP.
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-P300/CBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-P300/CBP antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-P300/CBP antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
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 Immunohistochemistry (IHC) of anti-P300/CBP antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using P300/CBP Antibody.
anti-P300/CBP antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-P300/CBP antibody    Western blot analysis of extracts from COLO205 cells, using P300/CBP Antibody.
anti-P300/CBP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for P300/CBP. It may not necessarily be applicable to this product.
 NCBI GI #    50345997
 NCBI GeneID    2033
 NCBI Accession #    NP_001420.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001429.3 [Other Products]
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 UniProt Primary Accession #    Q09472 [Other Products]
 UniProt Secondary Accession #    B1AKC2 [Other Products]
 UniProt Related Accession #    Q09472 [Other Products]
 Molecular Weight    264,161 Da
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 NCBI Official Full Name    histone acetyltransferase p300 isoform 1
 NCBI Official Synonym Full Names    E1A binding protein p300
 NCBI Official Symbol    EP300 [Similar Products]
 NCBI Official Synonym Symbols   
p300; KAT3B; RSTS2
[Similar Products]
 NCBI Protein Information    histone acetyltransferase p300
 UniProt Protein Name    Histone acetyltransferase p300
 UniProt Synonym Protein Names   
E1A-associated protein p300; Histone butyryltransferase p300 (EC:2.3.1.-
 UniProt Gene Name    EP300 [Similar Products]
 UniProt Synonym Gene Names    P300; p300 HAT [Similar Products]
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 NCBI Summary for P300/CBP    This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
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 UniProt Comments for P300/CBP    Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA) or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation or propionylation, respectively (PubMed:25818647, PubMed:17267393). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (E)-but-2-enoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393).
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Product References and Citations for anti-P300/CBP antibody

   Gerd A. Blobel, J. Leukoc. Biol., Apr 2002; 71: 545. Eric Kalkhoven, Hum. Mol. Genet., Feb 2003; 12: 441-450. Wei-fang Shen, Mol. Cell. Biol., Nov 2001; 21: 7509-7522. Frederick C. Nucifora, Science, Mar 2001; 291: 2423.
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 Research Articles on P300/CBP    1. These results reveal a novel RTK-AKT-p300-ADA3 signaling pathway involved in growth factor-induced cell cycle progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-P300/CBP antibodyPathways associated with anti-P300/CBP antibody
 Reference Product  PubMed Publications
 E1A antibody  >589 publications with P300/CBP and E1A
 CREBBP antibody  >115 publications with P300/CBP and CREBBP
 JUN antibody  >67 publications with P300/CBP and JUN
 SMAD3 antibody  >26 publications with P300/CBP and SMAD3
 MDM2 antibody  >26 publications with P300/CBP and MDM2
 RELA antibody  >24 publications with P300/CBP and RELA
 HIF1A antibody  >21 publications with P300/CBP and HIF1A
 CTNNB1 antibody  >17 publications with P300/CBP and CTNNB1
 NCOA1 antibody  >17 publications with P300/CBP and NCOA1
 SIRT1 antibody  >16 publications with P300/CBP and SIRT1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
Diseases associated with anti-P300/CBP antibodyOrgans/Tissues associated with anti-P300/CBP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >151 publications with P300/CBP and Neoplasms
 Necrosis Antibodies  >28 publications with P300/CBP and Necrosis
 Rubinstein-Taybi Syndrome Antibodies  >26 publications with P300/CBP and Rubinstein-Taybi Syndrome
 Inflammation Antibodies  >26 publications with P300/CBP and Inflammation
 Breast Neoplasms Antibodies  >25 publications with P300/CBP and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >18 publications with P300/CBP and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >16 publications with P300/CBP and Neoplasms, Experimental
 Lung Diseases Antibodies  >15 publications with P300/CBP and Lung Diseases
 Hypertrophy Antibodies  >15 publications with P300/CBP and Hypertrophy
 Liver Diseases Antibodies  >15 publications with P300/CBP and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >38 publications with P300/CBP and Heart
 Brain Antibodies  >26 publications with P300/CBP and Brain
 Kidney Antibodies  >23 publications with P300/CBP and Kidney
 Lung Antibodies  >18 publications with P300/CBP and Lung
 Skin Antibodies  >9 publications with P300/CBP and Skin
 Lymph Node Antibodies  >3 publications with P300/CBP and Lymph Node
 Stomach Antibodies  >2 publications with P300/CBP and Stomach
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