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TP63 antibody :: p40 (deltaNp63) Antibody

Scan QR to view Datasheet Catalog #    MBS438088
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p40 (deltaNp63) (TP63), Antibody

★Popular Item★
 Also Known As   

p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Rabbit Polyclonal Antibody

 Product Synonym Names    deltaNp63, TP63
 Product Gene Name   

TP63 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    103285
 3D Structure    ModBase 3D Structure for Q9H3D4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Cow
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 Specificity    p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody's ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques.
 Form/Format    200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
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 Cellular Localization    Nuclear
 Immunogen    A synthetic peptide (ENNAQTQFSEPQY) corresponding to aa5-17 of human p40
 Hu-Chromosome Location    3q28
 Positive Control    HEK293 cells or Prostate Carcinoma or Lung Squamous Cell Carcinoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of TP63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TP63 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for TP63 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilutions for a specific application should be determined.
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 Immunohistochemistry (IHC) of TP63 antibody    Formalin-fixed, paraffin-embedded Prostate Carcinoma stained with p40 Rabbit Polyclonal Antibody.
TP63 antibody  Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry of TP63 antibody    TP63 antibody  Immunohistochemistry (IHC) image
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 Western Blot of TP63 antibody    TP63 antibody  Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for TP63. It may not necessarily be applicable to this product.
 NCBI GI #    169234657
 NCBI GeneID    8626
 NCBI Accession #    NP_001108450.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114978.1 [Other Products]
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 UniProt Primary Accession #    Q9H3D4 [Other Products]
 UniProt Secondary Accession #    O75080; O75195; O75922; O76078; Q6VEG2; Q6VEG3; Q6VEG4; Q6VFJ1; Q6VFJ2; Q6VFJ3; Q6VH20 [Other Products]
 UniProt Related Accession #    Q9H3D4 [Other Products]
 Molecular Weight    40kDa
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 NCBI Official Full Name    tumor protein 63 isoform 2
 NCBI Official Synonym Full Names    tumor protein p63
 NCBI Official Symbol    TP63 [Similar Products]
 NCBI Official Synonym Symbols   
AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
[Similar Products]
 NCBI Protein Information    tumor protein 63
 UniProt Protein Name    Tumor protein 63
 UniProt Synonym Protein Names   
Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51
 Protein Family    Tumor protein
 UniProt Gene Name    TP63 [Similar Products]
 UniProt Synonym Gene Names    KET; P63; P73H; P73L; TP73L; p63; CUSP; TP63; p73L [Similar Products]
 UniProt Entry Name    P63_HUMAN
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 NCBI Summary for TP63    This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2016]
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 UniProt Comments for TP63    p63: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: cytoplasm; cytosol; dendrite; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: damaged DNA binding; double-stranded DNA binding; identical protein binding; p53 binding; protein binding; sequence-specific DNA binding; transcription factor activity; WW domain binding

Biological Process: apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1 DNA damage checkpoint; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein homotetramerization; regulation of apoptosis; regulation of epidermal cell division; regulation of neuron apoptosis; response to gamma radiation; response to X-ray

Disease: Adult Syndrome; Ankyloblepharon-ectodermal Defects-cleft Lip/palate; Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/palate Syndrome 3; Limb-mammary Syndrome; Rapp-hodgkin Syndrome; Split-hand/foot Malformation 4
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Product References and Citations for TP63 antibody

   Bishop, JA et. al. Modern Pathology 25 : 405-4152. Scagliotti G et. al. J Thorac Oncol 6:64-70. 3. Kargi A et. al. Appl Immunohistochem Mol Morphol 15:415-420
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 Research Articles on TP63    1. Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 in adjacent tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TP63 antibody Pathways associated with TP63 antibody
 Reference Product  PubMed Publications
 TP53 antibody  >137 publications with TP63 and TP53
 MDM2 antibody  >52 publications with TP63 and MDM2
 TP73 antibody  >23 publications with TP63 and TP73
 IRF6 antibody  >10 publications with TP63 and IRF6
 ITCH antibody  >6 publications with TP63 and ITCH
 PPP1R13L antibody  >3 publications with TP63 and PPP1R13L
 UBC antibody  >3 publications with TP63 and UBC
 SATB2 antibody  >2 publications with TP63 and SATB2
 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Intrinsic Pathway For Apoptosis antibodies  Intrinsic Pathway For Apoptosis Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with TP63 antibody Organs/Tissues associated with TP63 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >487 publications with TP63 and Carcinoma
 Neoplasms, Squamous Cell Antibodies  >303 publications with TP63 and Neoplasms, Squamous Cell
 Carcinoma, Squamous Cell Antibodies  >283 publications with TP63 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >188 publications with TP63 and Adenocarcinoma
 Abnormalities, Multiple Antibodies  >131 publications with TP63 and Abnormalities, Multiple
 Skin Abnormalities Antibodies  >112 publications with TP63 and Skin Abnormalities
 Lung Neoplasms Antibodies  >107 publications with TP63 and Lung Neoplasms
 Female Urogenital Diseases Antibodies  >97 publications with TP63 and Female Urogenital Diseases
 Cleft Palate Antibodies  >97 publications with TP63 and Cleft Palate
 Cleft Lip Antibodies  >96 publications with TP63 and Cleft Lip
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >214 publications with TP63 and Skin
 Lung Antibodies  >131 publications with TP63 and Lung
 Eye Antibodies  >94 publications with TP63 and Eye
 Prostate Antibodies  >73 publications with TP63 and Prostate
 Mouth Antibodies  >70 publications with TP63 and Mouth
 Embryonic Tissue Antibodies  >52 publications with TP63 and Embryonic Tissue
 Lymph Antibodies  >47 publications with TP63 and Lymph
 Bladder Antibodies  >43 publications with TP63 and Bladder
 Muscle Antibodies  >43 publications with TP63 and Muscle
 Thyroid Antibodies  >38 publications with TP63 and Thyroid
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