Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow p53  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Protein Kinase D1 (PKD1) ELISA Kit
 • Matrix protein 2 (M2) Recombinant Protein
 • mitochondrial respiratory chain complex III ELISA Kit
 • ATP synthase subunit delta (ATP5D) Recombinant Protein
 • SAA ELISA Kit
 • Heterogeneous nuclear ribonucleoprotein L (HNRNPL) Recombinant Protein
 • ring finger protein 43 (RNF43) ELISA Kit
 • ZBTB20 cDNA Clone
 • peptidylprolyl isomerase F (PPIF) ELISA Kit
 • IL-6 ELISA Kit
 • HIV-2 gp36 seq Peptide
 • A disintegrin and metalloproteinase with thrombospondin moti... ELISA Kit
 • PF-4708671 Inhibitor
 • Annexin A2 (ANXA2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-p53 antibody :: anti-Human p53 Antibody

Scan QR to view Datasheet Catalog #    MBS857020
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p53, Antibody

 Also Known As   

p53 (Phospho-Ser15) Antibody

 Product Synonym Names    A-T; mutated; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; Serine-protein kinase ATM; kinase ATM
 Product Gene Name   

anti-p53 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    133239
 3D Structure    ModBase 3D Structure for P04637
Section Bar
 Species Reactivity    Human
Section Bar
 Specificity    p53 (phospho-Ser15) antibody detects endogenous levels of p53 only when phosphorylated at serine15.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Section Bar
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 15 (P-L-SP-Q-E).
 All Sites    Human: Ser1981
Mouse: Ser1987
Section Bar
 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-p53 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-p53 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-p53 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-p53 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100-200
Section Bar
 Immunohistochemistry of anti-p53 antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (phospho- Ser15) antibody.
anti-p53 antibody Immunohistochemistry (IHC) image
Section Bar
 Western Blot of anti-p53 antibody    Western blot analysis of the extracts from HeLa cells untreated or treated with hydroxyurea, using p53 (Ab-15) antibody (Line1 and 2) and p53 (phospho-Ser15) antibody (Line3 and 4).
anti-p53 antibody Western Blot (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for p53. It may not necessarily be applicable to this product.
 NCBI GI #    120407068
 NCBI GeneID    7157
 NCBI Accession #    NP_000537.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000546.5 [Other Products]
Section Bar
 UniProt Primary Accession #    P04637 [Other Products]
 UniProt Secondary Accession #    Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98 [Other Products]
 UniProt Related Accession #    P04637 [Other Products]
 Molecular Weight    24,401 Da
Table BarTOPTable Bar
 NCBI Official Full Name    cellular tumor antigen p53 isoform a
 NCBI Official Synonym Full Names    tumor protein p53
 NCBI Official Symbol    TP53 [Similar Products]
 NCBI Official Synonym Symbols   
P53; BCC7; LFS1; TRP53
[Similar Products]
 NCBI Protein Information    cellular tumor antigen p53
 UniProt Protein Name    Cellular tumor antigen p53
 UniProt Synonym Protein Names   
Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
 Protein Family    p53 and DNA damage-regulated protein
 UniProt Gene Name    TP53 [Similar Products]
 UniProt Synonym Gene Names    P53 [Similar Products]
Section Bar
 NCBI Summary for p53    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Section Bar
 UniProt Comments for p53    Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Table BarTOPTable Bar
 

Product References and Citations for anti-p53 antibody

   Shieh, S. Y. et al. (1999) EMBO J. 18, 1815-1823. Honda, R. et al. (1997) FEBS Lett. 420, 25-27. Hirao, A. et al. (2000) Science 287, 1824-1827.
Section Bar
 Research Articles on p53    1. Low TP53 expression is associated with clear cell and endometrioid carcinoma of the ovary and the endometrium.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-p53 antibodyPathways associated with anti-p53 antibody
 Reference Product  PubMed Publications
 MDM2 antibody  >621 publications with p53 and MDM2
 CDKN1A antibody  >502 publications with p53 and CDKN1A
 BAX antibody  >316 publications with p53 and BAX
 BRCA1 antibody  >316 publications with p53 and BRCA1
 ATM antibody  >262 publications with p53 and ATM
 BRCA2 antibody  >227 publications with p53 and BRCA2
 PTGS2 antibody  >63 publications with p53 and PTGS2
 BCR antibody  >59 publications with p53 and BCR
 CHEK2 antibody  >55 publications with p53 and CHEK2
 BCL2L1 antibody  >53 publications with p53 and BCL2L1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of NOXA And Translocation To Mitochondria Pathway antibodies  Activation Of NOXA And Translocation To Mitochondria Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-p53 antibodyOrgans/Tissues associated with anti-p53 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2166 publications with p53 and Carcinoma
 Urogenital Neoplasms Antibodies  >938 publications with p53 and Urogenital Neoplasms
 Breast Neoplasms Antibodies  >851 publications with p53 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >591 publications with p53 and Colorectal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >521 publications with p53 and Carcinoma, Squamous Cell
 Glioma Antibodies  >459 publications with p53 and Glioma
 Cell Transformation, Neoplastic Antibodies  >318 publications with p53 and Cell Transformation, Neoplastic
 Carcinoma, Small Cell Antibodies  >314 publications with p53 and Carcinoma, Small Cell
 Neoplasm Metastasis Antibodies  >284 publications with p53 and Neoplasm Metastasis
 Sarcoma Antibodies  >273 publications with p53 and Sarcoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >704 publications with p53 and Blood
 Lung Antibodies  >567 publications with p53 and Lung
 Brain Antibodies  >479 publications with p53 and Brain
 Liver Antibodies  >291 publications with p53 and Liver
 Skin Antibodies  >256 publications with p53 and Skin
 Lymph Antibodies  >225 publications with p53 and Lymph
 Prostate Antibodies  >178 publications with p53 and Prostate
 Vascular Antibodies  >155 publications with p53 and Vascular
 Muscle Antibodies  >112 publications with p53 and Muscle
 Kidney Antibodies  >108 publications with p53 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions