NP_001076.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin family A member 3
NCBI Protein Information
alpha-1-antichymotrypsin
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Synonym Protein Names
Cell growth-inhibiting gene 24/25 protein; Serpin A3
UniProt Synonym Gene Names
UniProt Entry Name
AACT_HUMAN
NCBI Summary for SERPINA3
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINA3
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular region; extracellular space; nucleus
Molecular Function: DNA binding; protein binding; serine-type endopeptidase inhibitor activity
Biological Process: platelet degranulation
Research Articles on SERPINA3
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Pathways associated with SERPINA3 antigen
Diseases associated with SERPINA3 antigen
Organs/Tissues associated with SERPINA3 antigen
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