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SERPINA1 antigen :: Alpha 1 Antitrypsin Antigen

Scan QR to view Datasheet Catalog #    MBS568579 SERPINA1 antigen
Unit / Price
3 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha 1 Antitrypsin (SERPINA1), Antigen

 Also Known As   

Alpha 1 Antitrypsin Antigen >=95%

 Product Gene Name   

SERPINA1 antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107400
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 Host    Human Plasma
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Lyophilized from 30 mM sodium phosphate pH 6.5 with 300 mM NaCl
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 Preparation and Storage    Store at <=-20 degree C
 Other Notes    Small volumes of SERPINA1 antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for SERPINA1 antigen    Tumor Markers
 Applications Tested/Suitable for SERPINA1 antigen   

Immunogen Grade

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NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
 NCBI GI #    189163542
 NCBI GeneID    5265
 NCBI Accession #    NP_001121179.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127707.1 [Other Products]
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 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 UniProt Related Accession #    P01009 [Other Products]
 Molecular Weight    34,755 Da [Similar Products]
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 NCBI Official Full Name    alpha-1-antitrypsin
 NCBI Official Synonym Full Names    serpin family A member 1
 NCBI Official Symbol    SERPINA1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
[Similar Products]
 NCBI Protein Information    alpha-1-antitrypsin
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
 Protein Family    Alpha-1-antitrypsin
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI; SPAAT [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for SERPINA1    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA1    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular region; extracellular space; Golgi apparatus

Molecular Function: glycoprotein binding; identical protein binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; platelet degranulation

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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 Research Articles on SERPINA1    1. rs2896268 in SERPINA1 is associated with AAT level. rs671 in ALDH2, rs1169288 in HNF1A and rs1260326 in GCKR, significantly associate with AAT levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SERPINA1 antigenPathways associated with SERPINA1 antigen
 Reference Product  PubMed Publications
 FN1 antigen  >4 publications with SERPINA1 and FN1
 ALB antigen  >4 publications with SERPINA1 and ALB
 TIMP1 antigen  >3 publications with SERPINA1 and TIMP1
 A2M antigen  >2 publications with SERPINA1 and A2M
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
Diseases associated with SERPINA1 antigenOrgans/Tissues associated with SERPINA1 antigen
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >155 publications with SERPINA1 and Lung Diseases
 alpha 1-Antitrypsin Deficiency Antibodies  >151 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >138 publications with SERPINA1 and Liver Diseases
 Emphysema Antibodies  >127 publications with SERPINA1 and Emphysema
 Pulmonary Disease, Chronic Obstructive Antibodies  >67 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
 Pulmonary Emphysema Antibodies  >46 publications with SERPINA1 and Pulmonary Emphysema
 Inflammation Antibodies  >44 publications with SERPINA1 and Inflammation
 Liver Cirrhosis Antibodies  >32 publications with SERPINA1 and Liver Cirrhosis
 Fibrosis Antibodies  >23 publications with SERPINA1 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >21 publications with SERPINA1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >120 publications with SERPINA1 and Blood
 Liver Antibodies  >120 publications with SERPINA1 and Liver
 Lung Antibodies  >87 publications with SERPINA1 and Lung
 Skin Antibodies  >16 publications with SERPINA1 and Skin
 Vascular Antibodies  >13 publications with SERPINA1 and Vascular
 Heart Antibodies  >13 publications with SERPINA1 and Heart
 Kidney Antibodies  >12 publications with SERPINA1 and Kidney
 Pancreas Antibodies  >12 publications with SERPINA1 and Pancreas
 Bone Antibodies  >10 publications with SERPINA1 and Bone
 Muscle Antibodies  >7 publications with SERPINA1 and Muscle
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