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AMBP antigen :: Alpha-1-microglobulin Antigen

Scan QR to view Datasheet Catalog #    MBS7041626 AMBP antigen
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-1-microglobulin (AMBP), Antigen

★Popular Item★
 Also Known As   

Human Alpha-1-microglobulin protein

 Product Gene Name   

AMBP antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176870
 3D Structure    ModBase 3D Structure for P02760
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 Host    Yeast
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 Purity/Purification    >95% by SDS-PAGE
 Form/Format    Supplied in liquid form in 20 mM Tris, 500 mM NaCl, pH 8.0, 50% glycerol
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 Tag    His-tagged
 Activity    Protein concentration is determined >1mg/ml by commercial A1M Assay Kit by Latex
 Note    Applications are user defined. Product is developed as raw material and quality control tested in house, data is not provided on the data sheet. The researcher needs to establish and confirm the suitability of the product for their application.

Testing data may be available for this product regarding applications and assays the lab developed, please inquire.
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 Preparation and Storage    Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AMBP antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for AMBP antigen    Renal Function & Injury
 Applications Tested/Suitable for AMBP antigen   

ELISA (EIA), Latex Enhanced Turbidimetricimmunoassay (LETIA), Calibrator, Immunogen and other possible application.

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NCBI/Uniprot data below describe general gene information for AMBP. It may not necessarily be applicable to this product.
 NCBI GI #    579676
 NCBI GeneID    259
 NCBI Accession #    CAA38587.1 [Other Products]
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 UniProt Primary Accession #    P02760 [Other Products]
 UniProt Secondary Accession #    P00977; P02759; P78491; Q2TU33; Q5TBD7; Q9UC58; Q9UDI8 [Other Products]
 UniProt Related Accession #    P02760 [Other Products]
 Molecular Weight    38,999 Da
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 NCBI Official Full Name    alpha-1-microglobulin, partial
 NCBI Official Synonym Full Names    alpha-1-microglobulin/bikunin precursor
 NCBI Official Symbol    AMBP [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein AMBP
 UniProt Protein Name    Protein AMBP
 UniProt Synonym Protein Names   
Alpha-1-microglobulin; Protein HC
 Protein Family    Protein
 UniProt Gene Name    AMBP [Similar Products]
 UniProt Synonym Gene Names    HCP; ITIL; Protein HC; ITI-LC [Similar Products]
 UniProt Entry Name    AMBP_HUMAN
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 NCBI Summary for AMBP    This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AMBP    AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32-q33

Cellular Component: cell surface; extracellular region; extracellular space; intracellular membrane-bound organelle; plasma membrane

Molecular Function: calcium channel inhibitor activity; calcium oxalate binding; heme binding; IgA binding; protein binding; protein homodimerization activity; serine-type endopeptidase inhibitor activity

Biological Process: cell adhesion; female pregnancy; heme catabolic process; negative regulation of immune response; negative regulation of JNK cascade; protein catabolic process; protein-chromophore linkage; receptor-mediated endocytosis; viral reproduction
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 Research Articles on AMBP    1. Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AMBP antigenPathways associated with AMBP antigen
 Reference Product  PubMed Publications
 ALB antigen  >2 publications with AMBP and ALB
 SERPINC1 antigen  >2 publications with AMBP and SERPINC1
 SERPINA1 antigen  >1 publications with AMBP and SERPINA1
 ITIH1 antigen  >1 publications with AMBP and ITIH1
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
Diseases associated with AMBP antigenOrgans/Tissues associated with AMBP antigen
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >63 publications with AMBP and Cardiovascular Diseases
 Hypertension Antibodies  >46 publications with AMBP and Hypertension
 Inflammation Antibodies  >23 publications with AMBP and Inflammation
 Necrosis Antibodies  >16 publications with AMBP and Necrosis
 Kidney Diseases Antibodies  >14 publications with AMBP and Kidney Diseases
 Heart Diseases Antibodies  >12 publications with AMBP and Heart Diseases
 Liver Diseases Antibodies  >7 publications with AMBP and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >6 publications with AMBP and Drug-Induced Liver Injury
 Disease Models, Animal Antibodies  >5 publications with AMBP and Disease Models, Animal
 Liver Neoplasms Antibodies  >3 publications with AMBP and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with AMBP and Heart
 Liver Antibodies  >29 publications with AMBP and Liver
 Kidney Antibodies  >24 publications with AMBP and Kidney
 Intestine Antibodies  >14 publications with AMBP and Intestine
 Brain Antibodies  >14 publications with AMBP and Brain
 Muscle Antibodies  >7 publications with AMBP and Muscle
 Lung Antibodies  >5 publications with AMBP and Lung
 Pancreas Antibodies  >3 publications with AMBP and Pancreas
 Embryonic Tissue Antibodies  >2 publications with AMBP and Embryonic Tissue
 Spleen Antibodies  >1 publications with AMBP and Spleen
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