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A2M antigen :: Alpha 2 Macroglobulin Antigen

Scan QR to view Datasheet Catalog #    MBS568833 A2M antigen
Unit / Price
3 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha 2 Macroglobulin (A2M), Antigen

 Also Known As   

Alpha 2 Macroglobulin Antigen >=95%

 Product Gene Name   

A2M antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    103950
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 Host    Human Plasma
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Lyophilized from 30 mM Sodium Phosphate, pH 7.0 with glycine
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 Preparation and Storage    Store at <=-20 degree C
 Other Notes    Small volumes of A2M antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for A2M antigen    Serum Proteins
 Applications Tested/Suitable for A2M antigen   

Immunogen Grade

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NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
 NCBI GI #    66932947
 NCBI GeneID    2
 NCBI Accession #    NP_000005.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000014.4 [Other Products]
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 UniProt Secondary Accession #    Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97 [Other Products]
 UniProt Related Accession #    P01023 [Other Products]
 Molecular Weight    163,291 Da [Similar Products]
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 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2M [Similar Products]
 NCBI Official Synonym Symbols   
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 Protein Family    Alpha-2-macroglobulin
 UniProt Gene Name    A2M [Similar Products]
 UniProt Synonym Gene Names    CPAMD5; Alpha-2-M [Similar Products]
 UniProt Entry Name    A2MG_HUMAN
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 NCBI Summary for A2M    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
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 UniProt Comments for A2M    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: cytosol; extracellular region

Molecular Function: calcium-dependent protein binding; enzyme binding; growth factor binding; GTPase activator activity; interleukin-1 binding; interleukin-8 binding; protease binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; tumor necrosis factor binding

Biological Process: blood coagulation, intrinsic pathway; extracellular matrix disassembly; negative regulation of complement activation, lectin pathway; platelet degranulation; regulation of small GTPase mediated signal transduction

Disease: Alpha-2-macroglobulin Deficiency; Alzheimer Disease
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 Research Articles on A2M    1. we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with A2M antigenPathways associated with A2M antigen
 Reference Product  PubMed Publications
 APP antigen  >18 publications with A2M and APP
 ALB antigen  >6 publications with A2M and ALB
 APOA1 antigen  >4 publications with A2M and APOA1
 TGFB1 antigen  >3 publications with A2M and TGFB1
 SERPINF2 antigen  >2 publications with A2M and SERPINF2
 PLG antigen  >2 publications with A2M and PLG
 SERPINA1 antigen  >2 publications with A2M and SERPINA1
 KLK3 antigen  >1 publications with A2M and KLK3
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Intrinsic Pathway Of Fibrin Clot Formation antibodies  Intrinsic Pathway Of Fibrin Clot Formation Diagram
Diseases associated with A2M antigenOrgans/Tissues associated with A2M antigen
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >99 publications with A2M and Nervous System Diseases
 Mental Disorders Antibodies  >86 publications with A2M and Mental Disorders
 Alzheimer Disease Antibodies  >83 publications with A2M and Alzheimer Disease
 Inflammation Antibodies  >34 publications with A2M and Inflammation
 Liver Diseases Antibodies  >16 publications with A2M and Liver Diseases
 Necrosis Antibodies  >14 publications with A2M and Necrosis
 Lung Diseases Antibodies  >14 publications with A2M and Lung Diseases
 Fibrosis Antibodies  >13 publications with A2M and Fibrosis
 Disease Models, Animal Antibodies  >11 publications with A2M and Disease Models, Animal
 Liver Cirrhosis Antibodies  >8 publications with A2M and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >141 publications with A2M and Blood
 Liver Antibodies  >43 publications with A2M and Liver
 Brain Antibodies  >35 publications with A2M and Brain
 Vascular Antibodies  >20 publications with A2M and Vascular
 Lung Antibodies  >14 publications with A2M and Lung
 Prostate Antibodies  >11 publications with A2M and Prostate
 Heart Antibodies  >10 publications with A2M and Heart
 Bone Antibodies  >8 publications with A2M and Bone
 Ovary Antibodies  >7 publications with A2M and Ovary
 Intestine Antibodies  >6 publications with A2M and Intestine
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