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APOA1 antigen :: Apolipoprotein A-I Antigen

Scan QR to view Datasheet Catalog #    MBS7041640 APOA1 antigen
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein A-I (APOA1), Antigen

★Popular Item★
 Also Known As   

Human Apolipoprotein A-I

 Product Gene Name   

APOA1 antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    105200
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 Purity/Purification    >95% by SDS-PAGE
 Form/Format    Liquid
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 Antibody Type    Recombinant
 Special Promotion    Buy 1 get 20 ug FREE
 Note    Applications are user defined. Product is developed as raw material and quality control tested in house, data is not provided on the data sheet. The researcher needs to establish and confirm the suitability of the product for their application.

Testing data may be available for this product regarding applications and assays the lab developed, please inquire.
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 Preparation and Storage    Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of APOA1 antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for APOA1 antigen    Cardiovascular Disease
 Applications Tested/Suitable for APOA1 antigen   

Calibrator, Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for APOA1. It may not necessarily be applicable to this product.
 NCBI GI #    966751415
 NCBI GeneID    335
 NCBI Accession #    NP_001304950.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001318021.1 [Other Products]
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 UniProt Secondary Accession #    Q6LDN9; Q6Q785; Q9UCS8; Q9UCT8; A8K866 [Other Products]
 UniProt Related Accession #    P02647 [Other Products]
 Molecular Weight    30,778 Da
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 NCBI Official Full Name    apolipoprotein A-I isoform 2
 NCBI Official Synonym Full Names    apolipoprotein A1
 NCBI Official Symbol    APOA1 [Similar Products]
 NCBI Official Synonym Symbols   
apo(a)
[Similar Products]
 NCBI Protein Information    apolipoprotein A-I
 UniProt Protein Name    Apolipoprotein A-I
 UniProt Synonym Protein Names   
Apolipoprotein A1
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA1 [Similar Products]
 UniProt Synonym Gene Names    Apo-AI; ApoA-I; ProapoA-I [Similar Products]
 UniProt Entry Name    APOA1_HUMAN
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 NCBI Summary for APOA1    This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
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 UniProt Comments for APOA1    APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Endoplasmic reticulum; Secreted; Motility/polarity/chemotaxis; Lipid-binding; Secreted, signal peptide; Cell development/differentiation; Vesicle

Chromosomal Location of Human Ortholog: 11q23-q24

Cellular Component: cell surface; chylomicron; cytoplasmic vesicle; cytosol; early endosome; endocytic vesicle; endoplasmic reticulum lumen; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: apolipoprotein A-I receptor binding; apolipoprotein receptor binding; beta-amyloid binding; chemorepellent activity; cholesterol binding; cholesterol transporter activity; enzyme binding; high-density lipoprotein binding; identical protein binding; lipase inhibitor activity; phosphatidylcholine binding; phospholipid binding; phospholipid transporter activity; protein binding

Biological Process: adrenal gland development; axon regeneration in the peripheral nervous system; blood vessel endothelial cell migration; cellular protein metabolic process; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endothelial cell proliferation; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; integrin-mediated signaling pathway; lipoprotein biosynthetic process; lipoprotein metabolic process; negative chemotaxis; negative regulation of cytokine secretion during immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-1 beta secretion; negative regulation of lipase activity; neurite regeneration; organ regeneration; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; phospholipid efflux; phospholipid homeostasis; platelet degranulation; positive regulation of fatty acid biosynthetic process; positive regulation of hydrolase activity; positive regulation of lipoprotein lipase activity; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; protein amino acid oxidation; protein stabilization; receptor-mediated endocytosis; regulation of Cdc42 protein signal transduction; regulation of cholesterol absorption; regulation of protein amino acid phosphorylation; response to drug; response to estrogen stimulus; response to nutrient; retinoid metabolic process; reverse cholesterol transport; sequestering of lipid; transforming growth factor beta receptor signaling pathway; transmembrane transport; triacylglycerol catabolic process; vitamin transport

Disease: Amyloidosis, Familial Visceral; Hypoalphalipoproteinemia, Primary
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 Research Articles on APOA1    1. Identify C-terminal cleavage of apoA-I by human mast cell chymase as a novel mechanism leading to loss of its anti-inflammatory functions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOA1 antigenPathways associated with APOA1 antigen
 Reference Product  PubMed Publications
 APOB antigen  >584 publications with APOA1 and APOB
 APOE antigen  >173 publications with APOA1 and APOE
 ABCA1 antigen  >170 publications with APOA1 and ABCA1
 APOC3 antigen  >82 publications with APOA1 and APOC3
 CETP antigen  >71 publications with APOA1 and CETP
 LCAT antigen  >48 publications with APOA1 and LCAT
 APOA2 antigen  >47 publications with APOA1 and APOA2
 TTR antigen  >11 publications with APOA1 and TTR
 FGA antigen  >4 publications with APOA1 and FGA
 HNF4A antigen  >4 publications with APOA1 and HNF4A
 Products by Pathway  Pathway Diagram
 ABC Transporters In Lipid Homeostasis Pathway antibodies  ABC Transporters In Lipid Homeostasis Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
Diseases associated with APOA1 antigenOrgans/Tissues associated with APOA1 antigen
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >532 publications with APOA1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >330 publications with APOA1 and Atherosclerosis
 Dyslipidemias Antibodies  >213 publications with APOA1 and Dyslipidemias
 Heart Diseases Antibodies  >200 publications with APOA1 and Heart Diseases
 Inflammation Antibodies  >138 publications with APOA1 and Inflammation
 Hyperlipidemias Antibodies  >134 publications with APOA1 and Hyperlipidemias
 Coronary Artery Disease Antibodies  >119 publications with APOA1 and Coronary Artery Disease
 Hypertension Antibodies  >92 publications with APOA1 and Hypertension
 Hypercholesterolemia Antibodies  >74 publications with APOA1 and Hypercholesterolemia
 Liver Diseases Antibodies  >65 publications with APOA1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >931 publications with APOA1 and Blood
 Liver Antibodies  >217 publications with APOA1 and Liver
 Heart Antibodies  >186 publications with APOA1 and Heart
 Brain Antibodies  >43 publications with APOA1 and Brain
 Muscle Antibodies  >31 publications with APOA1 and Muscle
 Lung Antibodies  >30 publications with APOA1 and Lung
 Intestine Antibodies  >21 publications with APOA1 and Intestine
 Ovary Antibodies  >17 publications with APOA1 and Ovary
 Pancreas Antibodies  >9 publications with APOA1 and Pancreas
 Embryonic Tissue Antibodies  >4 publications with APOA1 and Embryonic Tissue
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