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ApoB antigen :: Apolipoprotein B (ApoB) Antigen

Scan QR to view Datasheet Catalog #    MBS568575 ApoB antigen
Unit / Price
1 mg  /  $385 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein B (ApoB), Antigen

 Also Known As   

Apolipoprotein B (ApoB) Antigen >=95%

 Product Gene Name   

ApoB antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107730
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 Host    Human Plasma
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Lyophilized from 10 mM sodium deoxycholate, pH 10.0, with 50 mM Na?CO? and 50 mM NaCl
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 Preparation and Storage    Store at <=-20 degree C
 Other Notes    Small volumes of ApoB antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for ApoB antigen    Serum Proteins
 Applications Tested/Suitable for ApoB antigen   

Immunogen Grade

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NCBI/Uniprot data below describe general gene information for ApoB. It may not necessarily be applicable to this product.
 NCBI GI #    553189
 NCBI GeneID    338
 NCBI Accession #    AAA51752.1 [Other Products]
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 UniProt Secondary Accession #    O00502; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8 [Other Products]
 UniProt Related Accession #    P04114 [Other Products]
 Molecular Weight    515,605 Da
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 NCBI Official Full Name    apolipoprotein B, partial
 NCBI Official Synonym Full Names    apolipoprotein B
 NCBI Official Symbol    APOB [Similar Products]
 NCBI Official Synonym Symbols   
FLDB; LDLCQ4; apoB-48; apoB-100
[Similar Products]
 NCBI Protein Information    apolipoprotein B-100
 UniProt Protein Name    Apolipoprotein B-100
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOB [Similar Products]
 UniProt Synonym Gene Names    Apo B-100; Apo B-48 [Similar Products]
 UniProt Entry Name    APOB_HUMAN
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 NCBI Summary for ApoB    This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ApoB    APOB: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Defects in APOB are a cause of familial hypobetalipoproteinemia type 1 (FHBL1). A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

Protein type: Secreted; Carrier; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p24-p23

Cellular Component: actin cytoskeleton; cell soma; chylomicron; cytoplasm; cytosol; early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome membrane; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane

Molecular Function: cholesterol transporter activity; heparin binding; low-density lipoprotein receptor binding; phospholipid binding; protein binding

Biological Process: artery morphogenesis; cellular protein catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; fertilization; in utero embryonic development; leukocyte migration; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; lipoprotein transport; nervous system development; post-embryonic development; receptor-mediated endocytosis; regulation of cholesterol biosynthetic process; response to carbohydrate stimulus; response to lipopolysaccharide; response to selenium ion; response to virus; retinoid metabolic process; sperm motility; spermatogenesis; triacylglycerol catabolic process; triacylglycerol mobilization

Disease: Hypercholesterolemia, Autosomal Dominant, Type B; Hypobetalipoproteinemia, Familial, 1
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 Research Articles on ApoB    1. Our findings demonstrate a maternal-specific association between a common APOB variant and adiposity, an association that was not previously detected in GWAS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ApoB antigenPathways associated with ApoB antigen
 Reference Product  PubMed Publications
 APOE antigen  >1561 publications with ApoB and APOE
 APOA1 antigen  >584 publications with ApoB and APOA1
 LDLR antigen  >530 publications with ApoB and LDLR
 LPL antigen  >250 publications with ApoB and LPL
 LPA antigen  >86 publications with ApoB and LPA
 APOC3 antigen  >65 publications with ApoB and APOC3
 MTTP antigen  >64 publications with ApoB and MTTP
 APOA2 antigen  >24 publications with ApoB and APOA2
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
Diseases associated with ApoB antigenOrgans/Tissues associated with ApoB antigen
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3672 publications with ApoB and Cardiovascular Diseases
 Dyslipidemias Antibodies  >3166 publications with ApoB and Dyslipidemias
 Atherosclerosis Antibodies  >2717 publications with ApoB and Atherosclerosis
 Hyperlipidemias Antibodies  >2567 publications with ApoB and Hyperlipidemias
 Coronary Disease Antibodies  >1944 publications with ApoB and Coronary Disease
 Heart Diseases Antibodies  >1695 publications with ApoB and Heart Diseases
 Hypercholesterolemia Antibodies  >1573 publications with ApoB and Hypercholesterolemia
 Hyperlipoproteinemia Type II Antibodies  >757 publications with ApoB and Hyperlipoproteinemia Type II
 Hypertriglyceridemia Antibodies  >653 publications with ApoB and Hypertriglyceridemia
 Liver Diseases Antibodies  >616 publications with ApoB and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8462 publications with ApoB and Blood
 Liver Antibodies  >2359 publications with ApoB and Liver
 Heart Antibodies  >1587 publications with ApoB and Heart
 Intestine Antibodies  >627 publications with ApoB and Intestine
 Kidney Antibodies  >449 publications with ApoB and Kidney
 Muscle Antibodies  >278 publications with ApoB and Muscle
 Brain Antibodies  >165 publications with ApoB and Brain
 Lung Antibodies  >147 publications with ApoB and Lung
 Spleen Antibodies  >59 publications with ApoB and Spleen
 Embryonic Tissue Antibodies  >58 publications with ApoB and Embryonic Tissue
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