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APOC2 antigen :: Apolipoprotein CII Antigen

Scan QR to view Datasheet Catalog #    MBS568608 APOC2 antigen
Unit / Price
0.1 mg  /  $385 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein CII (APOC2), Antigen

 Also Known As   

Apolipoprotein CII Antigen >95%

 Product Gene Name   

APOC2 antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    207750
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 Host    Human Plasma
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Lyophilized from 10 mM Ammonia Bicarbonate, pH 7.4
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 Preparation and Storage    Store at <=-20 degree C
 Other Notes    Small volumes of APOC2 antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for APOC2 antigen    Serum Proteins
 Applications Tested/Suitable for APOC2 antigen   

Immunogen Grade

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NCBI/Uniprot data below describe general gene information for APOC2. It may not necessarily be applicable to this product.
 NCBI GI #    32130518
 NCBI GeneID    344
 NCBI Accession #    NP_000474.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000483.4 [Other Products]
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 UniProt Secondary Accession #    Q9BS39; Q9UDE3; Q9UNK3; C0JYY4 [Other Products]
 UniProt Related Accession #    P02655 [Other Products]
 Molecular Weight    11,284 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein C-II
 NCBI Official Synonym Full Names    apolipoprotein C2
 NCBI Official Symbol    APOC2 [Similar Products]
 NCBI Official Synonym Symbols   
APO-CII; APOC-II
[Similar Products]
 NCBI Protein Information    apolipoprotein C-II
 UniProt Protein Name    Apolipoprotein C-II
 UniProt Synonym Protein Names   
Apolipoprotein C2
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOC2 [Similar Products]
 UniProt Synonym Gene Names    APC2; Apo-CII; ApoC-II; ProapoC-II [Similar Products]
 UniProt Entry Name    APOC2_HUMAN
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 NCBI Summary for APOC2    This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
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 UniProt Comments for APOC2    APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; early endosome; extracellular region; extracellular space

Molecular Function: lipase inhibitor activity; lipid binding; phospholipase activator activity; phospholipase binding; protein homodimerization activity

Biological Process: cholesterol efflux; cholesterol homeostasis; lipid catabolic process; lipoprotein metabolic process; negative regulation of catalytic activity; negative regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; retinoid metabolic process; reverse cholesterol transport

Disease: Apolipoprotein C-ii Deficiency
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 Research Articles on APOC2    1. The results highlight the importance of charge-pair interactions within the apoC-II fibril core
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOC2 antigenPathways associated with APOC2 antigen
 Reference Product  PubMed Publications
 APOE antigen  >238 publications with APOC2 and APOE
 LPL antigen  >202 publications with APOC2 and LPL
 APOB antigen  >156 publications with APOC2 and APOB
 APOA5 antigen  >46 publications with APOC2 and APOA5
 LMF1 antigen  >22 publications with APOC2 and LMF1
 APOC3 antigen  >20 publications with APOC2 and APOC3
 APOA2 antigen  >18 publications with APOC2 and APOA2
 APOA1 antigen  >17 publications with APOC2 and APOA1
 APOC4 antigen  >9 publications with APOC2 and APOC4
 LPA antigen  >6 publications with APOC2 and LPA
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with APOC2 antigenOrgans/Tissues associated with APOC2 antigen
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >279 publications with APOC2 and Dyslipidemias
 Cardiovascular Diseases Antibodies  >104 publications with APOC2 and Cardiovascular Diseases
 Hyperlipoproteinemia Type I Antibodies  >49 publications with APOC2 and Hyperlipoproteinemia Type I
 Liver Diseases Antibodies  >31 publications with APOC2 and Liver Diseases
 Kidney Diseases Antibodies  >28 publications with APOC2 and Kidney Diseases
 Brain Diseases Antibodies  >26 publications with APOC2 and Brain Diseases
 Fatty Liver Antibodies  >25 publications with APOC2 and Fatty Liver
 Immune System Diseases Antibodies  >25 publications with APOC2 and Immune System Diseases
 Obesity Antibodies  >23 publications with APOC2 and Obesity
 Inflammation Antibodies  >17 publications with APOC2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >150 publications with APOC2 and Liver
 Heart Antibodies  >85 publications with APOC2 and Heart
 Kidney Antibodies  >30 publications with APOC2 and Kidney
 Intestine Antibodies  >28 publications with APOC2 and Intestine
 Lung Antibodies  >23 publications with APOC2 and Lung
 Brain Antibodies  >17 publications with APOC2 and Brain
 Skin Antibodies  >7 publications with APOC2 and Skin
 Ovary Antibodies  >7 publications with APOC2 and Ovary
 Embryonic Tissue Antibodies  >6 publications with APOC2 and Embryonic Tissue
 Eye Antibodies  >5 publications with APOC2 and Eye
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