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ApoE antigen :: Apolipoprotein E (ApoE) Antigen

Scan QR to view Datasheet Catalog #    MBS568758 ApoE antigen
Unit / Price
0.05 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein E (ApoE), Antigen

 Also Known As   

Apolipoprotein E (ApoE) Antigen >=95%

 Product Gene Name   

ApoE antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104310
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 Host    Human Plasma
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Liquid
50 mM NH?HCO?, pH 8.0
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 Preparation and Storage    Store at <=-70 degree C
 Other Notes    Small volumes of ApoE antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for ApoE antigen    Serum Proteins
 Applications Tested/Suitable for ApoE antigen   

Immunogen Grade

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NCBI/Uniprot data below describe general gene information for ApoE. It may not necessarily be applicable to this product.
 NCBI GI #    705044152
 NCBI GeneID    348
 NCBI Accession #    NP_001289620.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001302691.1 [Other Products]
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 UniProt Secondary Accession #    Q9P2S4; B2RC15; C0JYY5 [Other Products]
 UniProt Related Accession #    P02649 [Other Products]
 Molecular Weight    36,154 Da
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 NCBI Official Full Name    apolipoprotein E isoform b
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    APOE [Similar Products]
 NCBI Official Synonym Symbols   
AD2; LPG; APO-E; LDLCQ5
[Similar Products]
 NCBI Protein Information    apolipoprotein E
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOE [Similar Products]
 UniProt Synonym Gene Names    Apo-E [Similar Products]
 UniProt Entry Name    APOE_HUMAN
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 NCBI Summary for ApoE    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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 UniProt Comments for ApoE    APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; cytoplasm; early endosome; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; membrane; nucleus; plasma membrane

Molecular Function: antioxidant activity; beta-amyloid binding; cholesterol binding; cholesterol transporter activity; heparin binding; identical protein binding; lipid binding; lipid transporter activity; low-density lipoprotein receptor binding; metal chelating activity; phospholipid binding; protein binding; protein homodimerization activity; tau protein binding

Biological Process: cGMP-mediated signaling; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cytoskeleton organization and biogenesis; fatty acid homeostasis; G-protein coupled receptor protein signaling pathway; intracellular transport; lipoprotein catabolic process; lipoprotein metabolic process; long-chain fatty acid transport; negative regulation of blood coagulation; negative regulation of blood vessel endothelial cell migration; negative regulation of cholesterol biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of MAP kinase activity; negative regulation of neuron apoptosis; neurite regeneration; nitric oxide mediated signal transduction; phospholipid efflux; positive regulation of cGMP biosynthetic process; positive regulation of lipid biosynthetic process; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric-oxide synthase activity; protein import; receptor-mediated endocytosis; regulation of axon extension; regulation of Cdc42 protein signal transduction; regulation of neuronal synaptic plasticity; retinoid metabolic process; reverse cholesterol transport; synaptic transmission, cholinergic; triacylglycerol catabolic process; triacylglycerol metabolic process; virus assembly

Disease: Alzheimer Disease 2; Alzheimer Disease 4; Lipoprotein Glomerulopathy; Macular Degeneration, Age-related, 1; Sea-blue Histiocyte Disease
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 Research Articles on ApoE    1. Healthy APOE epsilon4 carriers until the age of 65 years do not experience significantly different rates of cell division, cytotoxicity, and chromosomal DNA damage when compared with non-APOE epsilon4 carriers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ApoE antigenPathways associated with ApoE antigen
 Reference Product  PubMed Publications
 APOB antigen  >1561 publications with ApoE and APOB
 LDLR antigen  >643 publications with ApoE and LDLR
 LPL antigen  >343 publications with ApoE and LPL
 APOA1 antigen  >173 publications with ApoE and APOA1
 LRP1 antigen  >93 publications with ApoE and LRP1
 APOC3 antigen  >88 publications with ApoE and APOC3
 APOA2 antigen  >23 publications with ApoE and APOA2
 LRP8 antigen  >17 publications with ApoE and LRP8
 HSPG2 antigen  >7 publications with ApoE and HSPG2
 LRP2 antigen  >5 publications with ApoE and LRP2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
Diseases associated with ApoE antigenOrgans/Tissues associated with ApoE antigen
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6629 publications with ApoE and Cardiovascular Diseases
 Alzheimer Disease Antibodies  >6033 publications with ApoE and Alzheimer Disease
 Atherosclerosis Antibodies  >5330 publications with ApoE and Atherosclerosis
 Arteriosclerosis Antibodies  >4366 publications with ApoE and Arteriosclerosis
 Dyslipidemias Antibodies  >2121 publications with ApoE and Dyslipidemias
 Inflammation Antibodies  >1902 publications with ApoE and Inflammation
 Hyperlipidemias Antibodies  >1893 publications with ApoE and Hyperlipidemias
 Cognition Disorders Antibodies  >1545 publications with ApoE and Cognition Disorders
 Plaque, Atherosclerotic Antibodies  >1458 publications with ApoE and Plaque, Atherosclerotic
 Coronary Disease Antibodies  >1203 publications with ApoE and Coronary Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4774 publications with ApoE and Brain
 Vascular Antibodies  >4517 publications with ApoE and Vascular
 Liver Antibodies  >1997 publications with ApoE and Liver
 Heart Antibodies  >1751 publications with ApoE and Heart
 Muscle Antibodies  >1263 publications with ApoE and Muscle
 Nerve Antibodies  >672 publications with ApoE and Nerve
 Bone Antibodies  >640 publications with ApoE and Bone
 Kidney Antibodies  >546 publications with ApoE and Kidney
 Lung Antibodies  >315 publications with ApoE and Lung
 Spleen Antibodies  >266 publications with ApoE and Spleen
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