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CBLN1 antigen :: CEREBELLIN Antigen

Scan QR to view Datasheet Catalog #    MBS238026 CBLN1 antigen
Unit / Price
0.1 mg  /  $210 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEREBELLIN (CBLN1), Antigen

 Also Known As   

SYNTHETIC HUMAN CEREBELLIN

 Product Gene Name   

CBLN1 antigen

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Ser-Gly-Se r-Ala-Lys- Val-Ala-Ph e-Ser-Ala- Ile-Arg-Se r-Thr-Asn- His
 OMIM    600432
 3D Structure    ModBase 3D Structure for P23435
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 Purity/Purification    Peptide content is approximately 72% of total mass. Peptide purity is >99% by HPLC analysis
 Form/Format    Purified
Purified synthetic peptide - lyophilised.
 Concentration    Total protein concentration 1.0mg/ml after reconstitution. (lot specific)
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 Reconstitution    Reconstitute with 0.1ml sterile distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. Quantity listed reflects amount of puified peptide and not total mass which would include TFA counterions and residual water.
Preparation
 Buffer Solution    TFA salt.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of CBLN1 antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CBLN1 antigen

   Synthetic Human Cerebellin is a sixteen amino acid peptide corresponding to full-length human cerebellin, a secreted peptide derived from cleavage of cerebellin-1, a 193 amino acid (including signal peptide). Cerebellin has neuromodulatory functions including stimulating release of norepinephrine and adrenocortical secretion (Uniprot: P23435).
 Applications Tested/Suitable for CBLN1 antigen   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for CBLN1. It may not necessarily be applicable to this product.
 NCBI GI #    4757922
 NCBI GeneID    869
 NCBI Accession #    NP_004343.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004352.3 [Other Products]
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 UniProt Primary Accession #    P23435 [Other Products]
 UniProt Secondary Accession #    P02682; Q52M09; B2RAN9 [Other Products]
 UniProt Related Accession #    P23435 [Other Products]
 Molecular Weight    21,097 Da [Similar Products]
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 NCBI Official Full Name    cerebellin-1
 NCBI Official Synonym Full Names    cerebellin 1 precursor
 NCBI Official Symbol    CBLN1 [Similar Products]
 NCBI Protein Information    cerebellin-1; precerebellin
 UniProt Protein Name    Cerebellin-1
 UniProt Synonym Protein Names   
PrecerebellinCleaved into the following 2 chains:Cerebellin; CER; [des-Ser1]-cerebellin
 Protein Family    Cerebellin
 UniProt Gene Name    CBLN1 [Similar Products]
 UniProt Synonym Gene Names    CER [Similar Products]
 UniProt Entry Name    CBLN1_HUMAN
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 NCBI Summary for CBLN1    This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]
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 UniProt Comments for CBLN1    CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: postsynaptic membrane; extracellular region; cell junction

Molecular Function: protein homodimerization activity

Biological Process: heterophilic cell adhesion; positive regulation of synaptogenesis; nervous system development; synaptic transmission; protein secretion; cerebellar granule cell differentiation
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 Research Articles on CBLN1    1. Cbln1 and Cbln2 are co-expressed in the endolysosomal compartment of the thalamic neurons responsible for the synaptic alterations in striatum of Cbln1-null mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CBLN1 antigenDiseases associated with CBLN1 antigen
 Reference Product  PubMed Publications
 GLUD2 antigen  >11 publications with CBLN1 and GLUD2
 CBLN3 antigen  >11 publications with CBLN1 and CBLN3
 GRID2 antigen  >2 publications with CBLN1 and GRID2
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >10 publications with CBLN1 and Necrosis
 Brain Diseases Antibodies  >3 publications with CBLN1 and Brain Diseases
 Nerve Degeneration Antibodies  >2 publications with CBLN1 and Nerve Degeneration
 Disease Models, Animal Antibodies  >2 publications with CBLN1 and Disease Models, Animal
 Movement Disorders Antibodies  >1 publications with CBLN1 and Movement Disorders
 Prenatal Injuries Antibodies  >1 publications with CBLN1 and Prenatal Injuries
 Neurobehavioral Manifestations Antibodies  >1 publications with CBLN1 and Neurobehavioral Manifestations
 Pain Antibodies  >1 publications with CBLN1 and Pain
 Inflammation Antibodies  >1 publications with CBLN1 and Inflammation
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CBLN1 and Prenatal Exposure Delayed Effects
Organs/Tissues associated with CBLN1 antigen
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >50 publications with CBLN1 and Brain
 Embryonic Tissue Antibodies  >5 publications with CBLN1 and Embryonic Tissue
 Ganglia Antibodies  >2 publications with CBLN1 and Ganglia
 Ovary Antibodies  >2 publications with CBLN1 and Ovary
 Testis Antibodies  >2 publications with CBLN1 and Testis
 Uncharacterized Tissue Antibodies  >2 publications with CBLN1 and Uncharacterized Tissue
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